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Right Atrium
Right Ventricle
Pulmonary Trunk
Left Atrium
Left Ventricle
Coronary Arteries
Cardiac Veins
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Congenital Defects Tutorial
Introduction Normal Cardiac Development Part 1 Normal Cardiac Development Part 2 Septal Defects Right Heart Lesions Left Heart Lesions Anomalies of Arteries and Veins Cardiac Transplantation References
Overview of Major Embryonic Regions Development Timeline of Human Heart Embryology Primary Heart Tube Systemic and Pulmonary Circulation

Development Timeline of Human Heart Embryology

Human Development (days) Developmental Process
0 Fertilization
1-4 Cleavage and movement down the oviduct to the uterus
5-12 Implantation of the embryo into the uterus
13-14 Primitive streak formation (midstreak level contains precardiac cells)
15-17 Formation of the three primary germ layers (gastrulation): ectoderm, mesoderm, endoderm;
Midlevel primitive streak cells that migrate to an anterior and lateral position form the first heart field and more medially the second heart field
17-18 Lateral plate mesoderm splits into somatopleuric and mesoderm and splanchnopleuric mesoderm;
Splanchnopleuric mesoderm contains the myocardial and endocardial cardiogenic precursors in the region of the first heart field and second heart field
18-26 Neurulation (formation of the neural tube)
20 Cephalocaudal and lateral folding brings the bilateral endocardial tubes into the ventral midline of the embryo
21-22 Heart tube fusion
22 Heart begins to beat
22-28 Heart looping and accretion of cells from the first and second heart fields;
Proepicardial cells invest from the outer layer of the heart tube and eventually form the epicardium and coronary vasculature;
Neural crest migration starts
32-37 Cardiac neural crest migrates through the aortic arches and enters the outflow tract of the heart
57+ Outflow tract and ventricular septation complete
Birth Functional septation of the atrial chambers, as well as the pulmonary and systemic circulatory systems
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