Location:
Originate in ventricular wall; attached to anterior and posterior mitral valve cusps via chordae tendineae.

Function:
Prevents prolapse of anterior and posterior cusps of mitral valve during systole.

Importance in cardiovascular diseases:
Mitral valve insufficiency due to dysfunction or rupture of papillary muscle (coronary artery disease with papillary muscle ischemia and/or infarction).