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Paul A. Iaizzo, Ph.D.


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  Home > Personnel > Staff

Charles Soule, M.B.S.

B199 Mayo, MMC 195
420 Delaware Street S.E.
Minneapolis, MN 55455
Direct: (612) 626-2518
Fax: (612)624-2002


Master of Biological Sciences, Major Biology, Emphasis Physiology and Biochemistry
University of Minnesota Graduate School
Date of Graduation: July 2005

Bachelor of Science, Major Biology
University of Minnesota College of Biological Sciences
Date of Graduation: December 1992


Scientist, June 2002 to Current, University of Minnesota Medical School,
Department of Surgery, Section of Experimental Surgical Services
Promoted from Assistant Scientist November 2005
"Molecular preservation of skeletal and cardiac muscle from ischemic damage"

Assistant Scientist, November 1993 to June 2002, University of Minnesota Medical School, Department of Anesthesiology
Promoted from Principal Laboratory Technician March 1999
"Development of the large mammalian isolated working heart model -- The Visible Heart™"
"Understanding of cardiovascular anesthetic complications"

Senior Laboratory Technician, January 1991 to November 1993, University of Minnesota Medical School, Department of Medicine, Section of Infectious Diseases
Promoted from Undergraduate Research Assistant October 1992
"Characterization of the genotype and phenotype of select HSV I strains"
"Development of molecular testing for Lyme Disease"


1. Bandschapp O, Soule CL, and Iaizzo PA. Lactic acid restores skeletal muscle force in an in vitro fatigue model: are voltage-gated chloride channels involved? Am J Physiol Cell Physiol. 2012 Apr;302(7):C1019-25. Epub 2012 Jan 11.

2. Venkatasubramanian RT, Wolkers WF, Shenoi MM, Barocas VH, Lafontaine D, Soule CL, Iaizzo PA, Bischof JC. Freeze-thaw induced biomechanical changes in arteries: role of collagen matrix and smooth muscle cells. Ann Biomed Eng. 2010;38(3):694-706. Epub 2010 Jan 27.

3. Bandschapp O, Ginz HF, Soule CL, Girard T, Urwyler A, and Iaizzo PA. In vitro effects of propofol and volatile agents on pharmacologically induced chloride channel myotonia. Anesthesiology. 2009;111:584-90

4. Hong H, Sigg DC, Coles JA, Oeltgen PR, Harlow HJ, Soule CL, and Iaizzo PA. Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle. Muscle Nerve. 2005;32:200-7

5. Hill AJ, Laske TG, Coles JA, Sigg DC, Skadsberg ND, Vincent SA, Soule CL, Gallagher WJ, and Iaizzo PA. In vitro studies of human hearts. Ann Thorac Surg. 2005;79:168-77.

6. Chinchoy E, Soule CL, Houlton AJ, Gallagher WJ, Hjelle MA, Laske TG, Morissette J, Iaizzo PA. Isolated four-chamber working swine heart model. Ann Thorac Surg. 2000;70:1607-14.

7. Kehler CH, Hebl JR, Soule CL, Gallagher WJ, Houlton AJ. The effect of reduced myocardial cyclic AMP content on the response to milrinone in the isolated guinea pig heart. J Heart Lung Transplant. 1997;16:636-42.

8. Haanes EJ, Nelson CM, Soule CL, Goodman JL. The UL45 gene product is required for herpes simplex virus type 1 glycoprotein B-induced fusion. J Virol. 1994;68:5825-34.


1. Hebl JR, Houlton AJ, Soule CL, Kehler CH. The effect of sympathectomy on the response to milrinone in the isolated guinea pig heart. Anesthesiology 1995 Sept;83(3A): A626, 1995 Annual Meeting - American Society Of Anesthesiologists, Atlanta, Georgia

2. Haanes EJ, Nelson CM, Soule CL, Goodman JL. Suppression of a glycoprotein B syn Mutation in the HSV-1 CAM-Invasive recombinant F1 correlates with diminished invasiveness. 1992 17th International Herpesvirus Workshop, Edinburgh, Scotland


Contributor: The Visible Heart™ Viewer. Educational CD, Version 1.1, University of Minnesota and Medtronic Inc., December 2000.

Contributor: The Visible Heart™: A New View Into the Heart. Demonstration CD, University of Minnesota and Medtronic Inc., November 1999.

Contributor: The Human Body Gallery at the Science Museum of Minnesota, The Visible Heart™ display.

Presenter: University of Minnesota Community Heart Fair at the Science Museum of Minnesota. Presented Dr. Lillehei's prototype blood oxygenator, March 22 2003

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