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Advancing the Heart, a 501(c)(3) non-profit organization made a generous financial donation to our lab in support of research related to innovative cardiac technology.
Our lab was fortunate to receive two generous financial gifts from HLT, Inc. and The Wallin Foundation in November/December. This funding is dedicated to the support of graduate students and selected research projects.
CONGRATULATIONS to Paul Iaizzo on his 200th published manuscript in peer reviewed journals!!
The following manuscripts were recently accepted for publication:
Lars Mattison and Megan Schmidt hosted a cardiac anatomy exhibit at the LifeScience Alley 2014 conference at the Minneapolis Convention Center on November 19, 2014.
Megan Schmidt presented her research "Comparison of epicardial and endocardial monophasic action potentials recorded simultaneously from reanimated porcine hearts" at the Design of Medical Devices Europe Conference in The Netherlands (October 22-24, 2014).
Stephen Quallich presented his research poster "Changes in cardiac tissue properties relative to the applications of radiofrequency or cryo ablative therapies" at the BMES 2014 Conference in San Antonio, Texas (October 22-25, 2014).
Paul Iaizzo, along with Tinen Iles, Brian Howard, Stephen Quallich, Lars Mattison, Megan Schmidt, and Medical Device Center staff Dan Orban and John Huss hosted a 4-day hands-on exhibition of cardiac anatomy and physiology at the Transcatheter Cardiovascular Therapeutics (TCT) 2014 Annual Scientific Symposium in Washington DC (September 13-17, 2014).
PhD graduate students presented research posters at the TCT 2014 Annual Scientific Conference in Washington DC (September 13-17, 2014): 1) Stephen Quallich: A novel device for transseptal puncture to minimize iatrogenic atrial septal defect (co-authors: Mark Benscoter, Megan Schmidt, Lars Mattison, Salah El Haddi, Paul Iaizzo); and 2) Megan Schmidt: The recording of monophasic action potentials simultaneously from both the epicardial and endocardial surfaces of porcine hearts (co-authors: Tinen Iles, Gabriel Hernandez, Mark Benscoter, Dr. Michael Franz, Paul Iaizzo)
Paul Iaizzo delivered a keynote presetation at the 30th Annual Meeting of the Academy of Surgical Research at the Hyatt Regency Hotel in Minneapolis, MN on September 19, 2014.
Stephen Quallich won 1st place for his poster at the IEM Annual Conference & Retreat on September 22, 2014. Steve's research poster "Analyzing the perforation force before, during and following cardiac ablation" was awarded 1st place honors in the Cardiovascular Engineering division. Congrats Steve!
Ashish Singal successfully defended his PhD thesis on August 11, 2014. Thesis title: The comparative assessment of clinical ablative therapies: effects on physiological and biomechanical properties of tissues in response to therapeutic doses. Congratulations Ashish!
The following manuscripts were accepted for publication:
The Visible Heart Lab hosted a demonstration table at the Lillehei Heart Institute Tech Summit on June 11, 2014. The summit celebrated the 60th anniversary of cross-circulation and the 800th heart transplant at the University of Minnesota. Representatives from the VHL included: Paul Iaizzo, Brian Howard, Steve Quallich, Megan Schmidt, and Lars Mattison.
Paul Iaizzo, Lars Mattison, Salah James El Haddi, Brian Howard, Grant Gangeness, and Jeff Reineke hosted various hands-on cardiac educational activities at the AHA Heart Walk at Target Field on May 31, 2014.
Brian Howard, Paul Iaizzo and Tinen Iles traveled to Chicago for the Mimics Innovation Conference (May 15-16, 2014) where two posters were presented: 1) Human heart library and cardiac model reconstructions; and 2) Enhanced visual learning of cardiac anatomy via the painting of 3D heart models.
Cole Holmgren presented his graduate research on May 8, 2014, earning his masters degree in Biomedical Engineering. Cole has rejoined his medical school class (MD/MS Program). Congrats Cole!
VHL faculty, staff, and graduate students, together with Medical Device Center Fellows, hosted "A Heart to Learn" educational events at Transfiguration School in Oakdale (304 students, Kindergarten through 8th grade) and Scandia Elementary (200 students, 4th-6th grade) in April and May. Guided by "passports," students travel to six different stations to learn about cardiac anatomy, heart sounds, heart rates, cardiovascular history at the U of MN, cardiac devices, and heart health.
Paul Iaizzo and Michael Bateman (PhD, 2012) were co-authors on a poster presented at Heart Rhythm 2014 Conference in San Francisco (May 7-10, 2014). The title of the poster: 3D Anatomy of the Human Cardiac Conduction System and its Relationship to the Aortic Valve; other co-authors included: Halina Dobrzynski PhD, Andrew Atkinson MSc, Robert Anderson MD, FRCP, and Mark Boyett PhD.
Paul Iaizzo presented a talk on "Testing of Cardiac Ablative Devices Employing Visible Heart Methodologies" at the Society for Thermal Medicine Conference in Minneapolis on May 7, 2014.
Ashish Singal presented his research in poster format at the 14th International Symposium on Therapeutic Ultrasound (ITSU) in Las Vegas in April (April 2-5, 2014).
Rachel Drake was awarded the Big Ten Postgraduate Scholarship in April. This scholarship is awarded to two student-athletes from each of the 12 Big Ten institutions who plan to continue their education at a graduate degree program; scholarships were awarded primarily based on academic achievement. Congrats Rachel!
Stephen Quallich presented his poster "High-speed visualization of steam pops during radiofrequency ablation" at the Design of Medical Devices Conference in Minneapolis (April 8-10, 2014). Ryan Goff and Paul Iaizzo were co-authors.
VHL faculty, staff, graduate students, and volunteers hosted "A Heart to Learn" hands-on learning activity at the Design of Medical Devices Conference in Minneapolis (April 8-10, 2014).
On April 25, 2014, Paul Iaizzo made a lunchtime presentation and provided a lab tour for Department of Surgery members interested in learning more about the Visible Heart Lab. This was part of the deparmental Brown Bag Lunch Series.
Ryan Goff earned his PhD degree on March 4, 2014 after presenting his thesis entitled "Studies of Cryothermal Ablation for the Treatment of Atrial Fibrillation." Great job, Ryan!!
At the ACC Scientific Sessions in Washington DC (March 29-31, 2014), Stephen Quallich presented his poster entitled "Analyzing the perforation force of swine and human atria before, during and following cardiac ablation." Paul Iaizzo was a co-author.
Stephen Quallich traveled to Munich Germany for the European Cardiac Arrhythmia Society (ECAS) Conference in March 2014. He gave an oral presentation on his PhD research entitled "Acute pulmonary vein stenosis during and following ablations." Paul Iaizzo was a co-author.
Kevin Kriege was selected as a recipient of the 2014 Gregory Marzolf Jr. Undergraduate Research Fellowship. Congratulations Kevin!!
Paul Iaizzo and Megan Schmidt represented the Visible Heart Lab at the Muscular Dystrophy 2014 Lab Day on February 8, 2014. Participants learned about cardiac anatomy, physiology, and devices at the demonstration.
Brian Howard successfully passed his Oral Preliminary Exams on January 30, 2014. Great job!
Julianne Spencer successfully defended her PhD thesis "The implications and effects of coronary venous anatomy on clinical interventions" on November 27, 2013. Congratulations Dr. Spencer!
Ashish Singal presented his research poster, Tissue Response to Ablative Modalities, at the LifeScience Alley 2013 Conference (Healthcare Transformation-Surviving the Shift) on November 20, 2013. Co-authors included: Charles Soule, John Ballard, Erik Cressman, and Paul Iaizzo.
Paul Iaizzo, Ryan Goff, and Julianne Spencer collaborated with Medtronic at the American Heart Association 2013 Scientific Sessions (Dallas, TX) to provide a hands-on demonstration of cardiac anatomy.
Ryan Goff presented his poster "In vitro assessment of phrenic nerve cryothermal injury" at the American Heart Association 2013 Scientific Sessions in Dallas, TX in November.
Tinen Iles presented information about cardiac anatomy and physiology to ~75 6th graders at William Byrne Elementary in Burnsville on November 18, 2013.
Two posters were presented at the TCT 2013 Scientific Sessions in San Francisco, CA: 1) "Direct visualization of pulmonary vein ablations within reanimated swine hearts to investigate recent advances in cryo-balloon technologies" (Ryan Goff, Wyn Davies, Mark Benscoter, Stephen Howard, Paul Iaizzo) and 2) "Three dimensional reconstructions of the left phrenic nerve anatomy in relation to the coronary venous system" (Julianne Spencer, Ryan Goff, Paul Iaizzo)
Two posters were presented at the Marzolf Symposium at the University of Minnesota on October 30th: 1) "Simultaneous in vivo assessment of contractile properties and EMG activity in a knock-out mouse model of myotonic dystrophy" (Oliver Bandschapp, Charles Soule, Paul Iaizzo); 2) "Tissue response to ablative modalities" (Ashish Singal, Charles Soule, John Ballard, Erik Cressman, Paul Iaizzo)
Two Hands On Hearts youth educationals events were hosted in October 2013 at: 1) Camp Odayin (Amery, WI), a camp for families and their kids dealing with heart disease, and 2) Oak Park Elementary (Stillwater, MN), an educational opportunity for 260 4th-6th graders.
The manuscript "A detailed assessment of the human coronary venous system using contrast computed tomography of perfusion-fixed specimens" was accepted for publication in Heart Rhythm Journal. Congrats to co-authors Julianne Spencer, Allison Larson, Rachel Drake, and Paul Iaizzo!
Tinen Iles facilitated an educational event for ~40 preschool and kindergarten students at Wooddale Church in September 2013.
Robert Buechler presented his research project "Thermal tolerance of myocardium during cryoablation" and earned his Masters degree in Biomedical Engineering on October 8th, 2013. Congratulations, Robert!
The article "The benefits of the Atlas of Human Cardiac Anatomy website for the design of cardiac devices" was accepted for publication in Expert Review of Medical Devices. Congrats to co-authors Julianne Spencer, Jason Quill (PhD, 2009), Mike Bateman (PhD, 2012), Mike Eggen (PhD, 2009), Steve Howard (PhD, 2013), Ryan Goff, Brian Howard, Steve Quallich, and Paul Iaizzo.
Stephen Quallich passed his oral preliminaries on September 4, 2013. The title of his PhD studies is "Investigations of Tissue Property Changes and the Potential Complications Associated with Cardiac Ablation." Congratulations Steve!
Stephen Howard successfully defended his PhD thesis "Interatrial Septal Anatomy, Physiology and Biomechanics: Implications for Percutaneous Delivery of Cardiac Devices" on September 4, 2013. Congrats Dr. Howard!
On August 29th, several staff members, graduate students (current and former), medical students, and lab volunteers facilitated a hands on cardiac anatomy educational activity for Minnesota State Fairgoers. Thanks to Rob Colbert, Alice Lehman, Chris Rolfes, Melissa White, Brian Howard, Jules Spencer, Jenna Zimmerman, Mira Khatib, and Gary Williams for working at this community outreach event!!
Elizabeth Lezama and Ashley Scott presented research posters at the Life Sciences Summer Undergraduate Research Program Symposium at the McNamara Alumni Center on August 8th:
Dona Suardini presented her research titled "Tensile behavior of fresh porvine and ovine mitral valve chordae tendineae" and earned her Masters degree in Biomedical Engineering on July 22nd, 2013. Great job, Dona!
Paul Iaizzo co-authored a book chapter "Electro-physiological solutions for cardiac disease" along with Mike Eggen (PhD, 2009) and LJ Mulligan and JP Lalonde. This chapter can be found in Section V (Interventional Disease Treatment) of the 2nd edition of Biomedical Technology and Devices, published by CRC Press, Taylor & Francis in June 2013. Congrats to Paul and Mike!
Visible Heart Lab faculty, staff, graduate students, and medical students hosted Hands on Hearts demonstrations for the University of Minnesota Summer Camp program on July 17th and 19th, 2013. Guided by "passports," summer camp kids learned about heart anatomy, heart sounds, heart rates before and after exercise, cardiac devices, and heart-healthy life habits.
Faculty, staff, graduate students, and medical students facilitated a hands-on demonstration of human hearts on July 17th, 2013 at The Bakken Museum, as part of Best Days of the Bakken.
Several PhD graduate students presented posters at the Department of Surgery Research Day on June 10th, 2013:
Stephen Howard: 3D assessments of patent foramen ovale within human hearts: insights relative to design considerations for medical devices
Ryan Goff: In-vitro method for assessment of phrenic nerve injury
Stephen Quallich: Analyzing the parameters associated with radiofrequency ablation steam pop occurrences (also presented in Young Investigator Presentations)
Ashish Singal: Tissue response to ablative modalities
Julianne Spencer: 3-dimensional reconstructions of the human coronary artery system using contrast computed tomography of perfusion-fixed specimens
Stephen Howard presented his poster "3D assessments of patent foramen ovale within human hearts: insights relative to design considerations for medical devices" at the Minnesota Muscle Symposium at the University of Minnesota on June 7th, 2013.
Dr. Paul Iaizzo, Tinen Iles, Steve Quallich, Julianne Spencer and Cole Holmgren represented the Visible Heart Lab with a display at the American Heart Association Heart Walk May 4, 2013. The walk started from Target Field with over 20,000 participants.
Dr. Paul Iaizzo, Tinen Iles, Monica Mahre, and Brian Howard participated in the 2nd Annual Health and Safety Fair at Shattuck St. Mary's on April 19, 2013. This was a LHI-sponsored outreach program to educate youth on cardiac anatomy and physiology, as well as heart health.
Paul Iaizzo presented the keynote lecture "The Visible Heart® Laboratory and the Atlas of Human Cardiac Anatomy” for the Northern Ohio Cardiac Imaging Association at University Hospital, Case Medical Center (Cleveland Ohio) on April 13, 2013.
Congratulations to Paul Iaizzo who was selected to join the Institute for Engineering in Medicine (IEM) Academy of Medical Device Innovators, an award that honors those who have made innovations in medical devices leading to a great impact on the lives of patients. Dr. Iaizzo received a plaque to honor his induction into the 2013 class of the Academy on Wednesday, April 10th. Additionally, he was awarded the IEM Director's Award for championing IEM's mission. See details
Dr. Paul Iaizzo, Tinen Iles, Monica Mahre, and Brian Howard participated in the 2nd Annual Health and Safety Fair at Shattuck St. Mary's on April 19, 2013. This was a LHI-sponsored outreach program to educate youth on cardiac anatomy and physiology, as well as heart health.
Paul Iaizzo presented the keynote lecture "The Visible Heart® Laboratory and the Atlas of Human Cardiac Anatomy” for the Northern Ohio Cardiac Imaging Association at University Hospital, Case Medical Center (Cleveland Ohio) on April 13, 2013.
Video article "Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens" was recently published in the Journal of Visualized Experiments. Congratulations to co-authors Julianne Spencer, Emily Fitch, and Paul Iaizzo!
Heart Valves: From Design to Clinical Implanatation was released in March 2013! This 17-chapter book published by Springer is a practical, state-of-the-art handbook dedicated to: 1) cardiac valve anatomy, 2) models for testing and research methods, 3) clinical trials, and 4) clinical needs and applications. Paul Iaizzo and Alex Hill (PhD, 2003) teamed up with Richard Bianco and Dr. James St. Louis to edit this specialized handbook, and several current and former graduate students of the Visible Heart Lab contributed chapters.
The Journal of Cardiovascular Translational Research Special Issue on Cardiac Anatomy was published by Springer in April 2013. Drs. Paul Iaizzo, Robert Anderson, and Alex Hill (PhD, 2003) were guest co-editors of this special issue which features 13 invited articles that focus on attitudinally correct anatomic nomenclature to facilitate cross disciplinary research from bench to bedside. Current and former graduate students of the Visible Heart Lab contributed articles.
Our faculty and graduate students presented various posters at the Design of Medical Devices Conference (April 9-11, 2013) at The Commons Hotel in Minneapolis including: 1) 3-Dimensional Reconstructions of the Human Coronary Artery System using Contrast Computed Tomography of Perfusion-fixed Specimens (co-authors Julianne Spencer, Matt Venegoni, and Paul Iaizzo), 2) Conus Arteriosus: An Alternate Pacing Site (co-authors Ashish Singal, Noora Hussain, Robert Marcaccini, Anthony Weinhaus, and Paul Iaizzo), 3) Device Optimization using Pulse Wave Analysis Techniques (co-authors Ashish Singal, Mitsuhiro Oura, Mohamed Almekkawy, Aimee Hamel, Matt Larson, and Peter Eckman), 4) Irreversible Electroporation of Cardiovascular Cells and Tissues (co-authors Chunlan Jiang, Ryan Goff, Pong Patana-anake, Paul Iaizzo, and John Bischof), and 5) 3D Assessments of Patent Foramen Ovale within Human Hearts: Insights Relative to Design Considerations for Medical Devices (co-authors Stephen Howard and Paul Iaizzo).
Congratulations to Paul Iaizzo was selected to join the Institute for Engineering in Medicine (IEM) Academy of Medical Device Innovators, an award that honors those who have made innovations in medical devices leading to a great impact on the lives of patients. Dr. Iaizzo received a plaque to honor his induction into the 2013 class of the Academy on Wednesday, April 10th. Additionally, he was awarded the IEM Director's Award for championing IEM's mission. See details
Wound Healing during Hibernation by Black Bears (Ursus Americanus) in the Wild: Elicitation of Reduced Scar Formation was voted one of the favorite articles in 2012 by the editorial board of Integrative Zoology.
Ashish Singal passed the oral preliminary exams on January 28th for his PhD studies on "Changes in physiological and biomechanical properties of tissue following treatment by different ablative modalities." CONGRATULATIONS Ashish!
Dr. Paul Iaizzo presented a talk The Visible Heart : Voyage à l'intérieur du coeur at the Journées Européennes de la Société Française de Cardiologie in Paris on January 19th.
A photo of a swine heart on the isolated heart apparatus, published in MPR News in January, was chosen as one of the 2012 MPR Photos of the Year.
Tim Laske (PhD, 2004) was recently elected to the AIMBE 2013 College of Fellows. Each year the American Institute for Medical and Biological Engineering acknowledges leaders in medical and biological engineering across all arenas--academic, industry, and government. Tim will be inducted into the College of Fellows during the AIMBE 22nd Annual Event in Washington DC, February 17-19, 2013. CONGRATULATIONS, TIM!!!
Paul Iaizzo and Will Durfee participated in the annual Innovations in Cardiovascular Interventions (ICI) meeting December 2-4 in Tel-Aviv, Israel. This meeting focused on innovative technology and therapies, covering all stages of the innovation process from the bench to the patient bedside. Drs. Iaizzo and Durfee presented during the Academy of Innovation portion of the meeting--"Developing New Cardiovascular Therapies: The Process and Roles of the Key Opinion Leader."
Paul Iaizzo was featured as a keynote speaker for the 20th Annual Congress of the International Society for Rotary Blood Pumps in Istanbul, Turkey (September 20-22, 2012). The title of his keynote presentation was "Back to the Future: Laboratory Research on the Isolated Heart to Enhance Cardiovascular Device Design."
Dr. Dave Garshelis was featured in the Fall 2012 Minnesota Alumni Association magazine. Check out the article, "The Secret Lives of Bears."
Our two LSSURP undergraduate students presented posters at the Summer Undergraduate Research Symposium (McNamara Alumni Center) on August 9, 2012:
Jules Eggum and Tinen Healy Iles presented three posters at Cardio Palooza 4, the U of MN Celebration of Discovery in Cardiovascular Science and Medicine on August 1, 2012: 1) Digital 3D reconstruction of the coronary arteries and cardiac veins of persusion fixed human hearts using contrast computed tomography; 2) 3D reconstructions of the human cardiac venous system using contrast computed tomography for anatomical evaluation; and 3) The Atlas of Human Cardiac Anatomy: A Free-Access Educational Website.
The IEEE Engineering in Medicine and Biology Society (EMBS) recently launched a video highlighting ongoing research in the Visible Heart Laboratory. Check out http://www.embs.org/videos (look under "Laboratory Profiles").
Ivan Akunovich presented his Plan B Masters Thesis "Development of three-dimensional cardiac models with MIMICs software" on June 14th. Congratulations on earning your masters degree in Biomedical Engineering, Ivan!
Visible Heart staff and graduate students hosted a hands-on demonstration of cardiac anatomy at the American Heart Association Heart Walk at Target Field on May 19th.
Mike Bateman earned his PhD degree in Biomedical Engineering on May 7th after presenting his thesis "Investigations into the effects of transcatheter valve implantations on the cardiac conduction system and cardiac anatomy." Congrats Dr. Bateman!
Chris Rolfes successfully defended his PhD thesis on May 4, 2012 (Title: Intrapericardial delivery of omega-3 polyunsaturated fatty acids). Congratulations to Dr. Rolfes!
"The design and use of an optical mapping system for intracardiac electrical signaling," co-authored by Maneesh Shrivastav, Megan Ghai, Ashish Singal, and Paul Iaizzo, will be published in the Indian Pacing and Electrophysiology Journal. Congrats to all!
Matt Venegoni presented his Masters Capstone project "Mapping the coronary arteries using 3D reconstructions" on April 30th. Congratulations Matt!
Amanda (Martel) Wilson presented her masters Plan B project "Analyses of left ventricular volumes and wall thicknesses of perfusion fixed human hearts using magnetic resonance imaging and echocardiography" on April 16th. Congratulations on earning your masters degree in Biomedical Engineering, Amanda!!
PhD graduate student Julianne Eggum will present two posters at the Heart Rhythm Society 2012 Annual Conference in Boston:
PhD graduate students will present six posters at the Experimental Biology 2012 Annual Conference in San Diego:
PhD graduate students were awarded two What If? grants from the Institute for Engineering in Medicine starting in April 2012: Julianne Eggum (Mapping of the coronary veins) and Ryan Goff (Prototype development of a biodegradable intracoronary shunt). Congratulations!
Paul Iaizzo was inducted into the AIMBE 2012 College of Fellows for outstanding contributions to research and education in translational systems physiology and cardiovascular engineering at a ceremony in Washington DC on February 20th. Congratulations on this achievement!
Paul Iaizzo and Tinen Healy represented the Visible Heart Lab at the University of Minnesota Wellstone Muscular Dystrophy Center Lab Day and Open House on February 11, 2012. They hosted a table featuring our research on skeletal muscle.
Congrats to Paul Iaizzo on his recently published article "Therapeutic hypothermia in stroke and traumatic brain injury" in Frontiers in Neurology (co-authors: Alireza Faridar, Eric Bershad, Tenbit Emiru, Jose Suarez, and Afshin Divani)!
Congratulations to Paul Iaizzo, Jules Eggum, and Ryan Goff for securing a $40,000 IEM Seed Grant for research on "Quantification and Modeling of the Human Phrenic Nerve Anatomy." Great job!
Paul Iaizzo is co-investigator on a new IEM Seed Grant Award "An Abnormal Detrusor Muscle Contraction Mapping Approach in Optimizing BTX Injection in Treating OAB" along with Drs. Yingchun Zhang, Nissrine Nakib, Art Erdman, and Gerald Timm.
Paul Iaizzo and Will Durfee participated in the annual Innovations in Cardiovascular Interventions (ICI) meeting December 4-6 in Tel-Aviv, Israel. This meeting focused on innovative technology and therapies, covering all stages of the innovation process from the bench to the patient bedside. Presentations from international and Israeli experts highlighted new therapies and research at various levels of development, along with live case presentations to present the impact of these technologies on current and future therapy. Drs. Iaizzo and Durfee presented during the Academy of Innovation portion of the meeting.
Tinen Healy joined the Visible Heart Lab as an Assistant Scientist in December. Tinen graduated from Bethel University with a BS degree in biology in 2005, and has experience as a study director for preclinical research studies. She joined the University of Minnesota in 2010 as a research subjects compliance specialist, and brings with her a solid knowledge of compliance issues in research. Welcome Tinen!
Paul Iaizzo and the research team take time out for a picture during bear studies in Camp Ripley in December. Back row: Steve Howard, Mark Benscoter, and Chris Rolfes. Front row: Paul Iaizzo, Stephen Quallich, Beth Kregel, Jenna Zimmerman, Lesa Nord, and Tim Laske.
Paul Iaizzo was elected to the College of Fellows by the American Institute for Medical and Biological Engineering (AIMBE) for outstanding contributions to research and education in translational systems physiology and cardiovascular engineering. The inductees, who were nominated by their peers, were screened committees of Fellows within their specialty and were finally elected by the full College as the official College of Fellows Class of 2012.
The College of Fellows is comprised of the top two percent of medical and biological engineers in the country. Engineering and medical school chairs, research directors, innovators, and successful entrepreneurs, comprise the College of Fellows to pursue AIMBE’s mission to provide leadership and advocacy in medical and biological engineering for the advancement of society.
Ashish Singal has been selected as a Medical Devices Center Senior Innovation Fellow for 2011-2012. In this role, Ashish will be a member of an eight person cross-disciplinary team consisting of postgraduate engineers, seasoned medical device professionals, bio-scientists, and physicians. They will dedicate the next year to the creation of new medical devices to improve human health and well being. Congratulations Ashish! For more details, see Innovation Fellows Program.
Ryan Goff and Jules Eggum passed their oral preliminary exams during the week of September 12th and are now PhD Candidates. Congrats!
The manuscript "Cardiac remodeling as a consequence of atrial fibrillation: an anatomical study of perfusion-fixed human heart specimens" was accepted for publication in the Journal of Geriatric Cardiology. Congrats to co-authors Chris Rolfes, Steve Howard, Ryan Goff, and Paul Iaizzo!
The Visible Heart Lab joined Experimental Surgical Services and the Medical Devices Center in the University of Minnesota Building at the Minnesota State Fair on Thursday, September 1st. On display were several human hearts, cardiac devices, and the Atlas of Human Cardiac Anatomy. Thanks to all the graduate students and undergraduate volunteers that worked at the table (Mike Bateman, Chris Rolfes, Steve Howard, Ryan Goff, Jules Eggum, Brian Howard, Lesa Nord, and Allison Larson)!
We were honored to host Dr. Earl Bakken in the Visible Heart Lab on Tuesday, August 9th. Dr. Bakken toured the lab and talked with staff, graduate students, and Medtronic colleagues about their current research projects. During the visit, we experienced a power outage (due to light rail construction) which required us to navigate with backup OR lights, flashlights, and candles. Many found this interesting, as it was the threat of a power outage that spurred Dr. Walt Lillehei to challenge Dr. Bakken to create a battery-powered pacemaker in the 1950s.
Dionna Gamble (University of Maryland, Baltimore) and Nia Patterson (Occidental College, CA) completed research projects in the lab this summer as part of the Life Sciences Summer Undergraduate Research Program (LSSURP). On Thursday, August 11th, they presented their posters at the Summer Undergraduate Research Symposium:
Ryan Goff and Jules Eggum presented posters at the Department of Surgery Research Day on June 13th (University of Minnesota):
The Visible Heart Lab was represented at the American Heart Association Heart Walk at the Target Field on June 4th. Graduate students Steve Howard, Mike Bateman, Jules Eggum, Ryan Goff, and Alex Ryan shared their knowledge about cardiac anatomy and physiology, the Atlas of Human Heart Anatomy, and cardiac devices.
Several staff members and graduate students presented posters at the 2011 Muscle Symposium, including the following:
Tim Laske (PhD, 2004) received the 2011 Design of Medical Devices Conference Award. As the award recipient, Tim presented the keynote "Innovation on the Edge - Bears, Hearts, and Treating the Globe" at the conference luncheon on April 13th. Congratulations on a well deserved award, Tim!
Several staff members and graduate students presented posters at the Design of Medical Devices Conference, April 12-14, 2011 including:
Graduate students and undergraduate volunteers in the Visible Heart Lab hosted the "Hands on Heart Exhibit" at the Design of Medical Devices Conference, April 12-14, 2011. DMD participants (including Goldy) were able to view human hearts, experiment with echocardiography equipment, and navigate the Atlas of Human Heart Anatomy.
Paul Iaizzo presented "Translational research: from the bear den to the patient bedside" at a special bonus session for the Mini Medical School on Monday, March 21st (podcast). In addition, our graduate students manned various tables for the experiential activity that night, including displays of human hearts, bear research materials, the Atlas of Human Cardiac Anatomy, and an infrared camera for thermal imaging.
"Three-dimensional imaging of ventricular activation and electrograms from intracavitary recordings" was published in IEEE Transactions on Biomedical Engineering (April 2011 issue, pages 868-75). Congrats to co-authors Chenguang Liu, Paul Iaizzo, and Bin He!
The manuscript "Multimodal imaging of a transcatheter aortic valve implantation within an isolated heart" will be published in an upcoming issue of JACC: Cardiovascular Imaging. Congratulations to co-authors Jason Quill (PhD, 2009), Alex Hill (PhD, 2003), Ana Menk, Brian McHenry, and Paul Iaizzo!
One portion of the BBC video "How to Mend a Broken Heart" featured Paul Iaizzo and the Visible Heart Laboratory and our research procedure to reanimate hearts on an apparatus for the study of functional cardiac anatomy. In this way, we can better visualize and understand the delicate, yet complex, anatomy of the heart to improve our ability to create new devices and treatments for individuals with cardiac problems. This video was released in the UK on February 14, 2011.
Paul Iaizzo was featured in a Minnesota Public Radio broadcast on Tuesday, March 15. The report focused on his research on bear hibernation that has the potential to lead to drug development for humans to help fight atrophy. Story and pictures are available at: http://minnesota.publicradio.org/display/web/2011/03/14/photos-bear-researcher/
Medtronic hosted a luncheon on March 11th to celebrate the continuing research collaboration between Medtronic and the Visible Heart lab. Speakers included Drs. Nick Skadsberg (PhD, 2004), Mike Eggen (PhD, 2009), and Tim Laske (PhD, 2004) from Medtronic, as well as Drs. Paul Iaizzo and Frank Cerra from the University of Minnesota. In addition, they led tours of their Mounds View campus and Bakken Educational Center (Hospital of the Future). Thanks to Medtronic for a wonderful event!!
Oliver Bandschapp and Paul Iaizzo co-authored a manuscript "Induction of therapeutic hypothermia requires modulation of thermoregulatory defenses" that will be published in Therapeutic Hypothermia and Temperature Management. Great work!
Congratulations to George Mallin who successfully defended his Masters (Mechanical Engineering) thesis on Monday, February 28th. The title of his presentation was "Atrial pre-load automation in the Visible Heart apparatus". In addition, George will start his new job as Associate Mechanical Designer for Medtronic in Montreal on March 14th. Best of luck, George!
Paul Iaizzo and Tim Laske (PhD, 2004) teamed up on a presentation for the Young Scientist Program for Wayzata Public Schools on February 1st. They described how academia and industry work together to conduct research on black bears in Minnesota.
In collaboration with other researchers, our lab recently published the following manuscripts:
Co-authored by Dr. David Schultz, Dr. Xiaohong Zhou, Ashish Singal, and Shailesh Musley (Post-doctoral fellow, 1996-99), the manuscript "Cardiovascular effects of spinal cord stimulation in hypertensive patients" will be published in Pain Physician in the first part of 2011. Congrats to all co-authors!
Three undergraduate students will receive UROP awards for pursuing research projects in the lab. Congratulations to Dan Balto (Title: Biomechanical punture study on the fossa ovalis of human and pig hearts), Maria Zauner (Title: Construction of a phrenic nerve stimulation apparatus), and Kiley Schmidt (Title: Educational visuals creation for the Atlas of Human Cardiac Anatomy).
Congratulations to Eric Richardson (PhD, 2009), Yong-Fu Xiao, and Paul Iaizzo on the news that their manuscript "Electrophysiological Mechanisms of the Anti-arrhythmic Effects of Omega-3 Fatty Acids" was accepted for publication in the Journal of Cardiovascular Translational Research. The manuscript is slated for publication in the January 2011 issue.
The Executive Committee of the Design of Medical Devices Conference chose Tim Laske (PhD, 2004) as the recipient of the 2011 Design of Medical Devices Conference Award. This award was established to recognize individuals who have made significant contributions to the Medical Device Community within the State, by helping build and strengthen interrelationships amongst the vital components of this Industry. As the award winner, Tim was invited to be a Keynote Speaker during the award luncheon portion of the DMD conference which will be April 12-14, 2011. We're proud of you, Tim!
The abstract entitled "Effects of Pericardial Application of Omega-3 Fatty Acids on Atrial Fibrillation," co-authored by Kojo Yeboa (LSSURP student, 2010) and Paul Iaizzo, has been accepted for presentation at the 2010 Annual Biomedical Research Conference for Minority Students (ABRCMS) on November 12, 2010. Congratulations!
Steve Howard passed his Oral Preliminary Exam on Friday, September 10th; his thesis title was "Attenuation of Cardiac Injury Following Ischemia with Omega-3 Fatty Acid Emulsions." Congratulations Steve!!
Visible Heart Lab graduate students and first year UM medical students manned a booth at the Minnesota State Fair on Thursday, September 2nd. They demonstrated human heart specimens, as well as various cardiac devices and the Atlas of Human Cardiac Anatomy.
Undergraduate students Maria Zauner (University of Minnesota) and KC Yeboa (University of Maryland, Baltimore) presented posters at the LSSURP Poster Symposium at the University of Minnesota on August 13th. These posters highlighted the results of their summer research in the Visible Heart Lab.
|Maria Zauner Poster: Assessment of the Cardiac Conduction System Using Trans-mural Electrodes||KC Yeboa Poster: Effects of Pericardial Application of Omega-3 Fatty Acids on Atrial Fibrillation|
Paul and Marge Iaizzo hosted a fabulous pig roast at their home in July to celebrate the signing of the 5-year contract extension with Medtronic. Since 1997, Paul has worked closely with research colleagues at Medtronic to develop the Visible Heart Laboratory which is now considered a premiere place to perform translational systems physiology research ranging from cellular and tissue studies to organ and whole body investigations.
Mark Hjelle, Tim Laske, and Paul Iaizzo,
Originators of the Visible Heart Lab
Tim Laske presenting Paul Iaizzo
with commemorative picture collage
|Visible Heart Lab staff and students (current and alumnae)|
Visible Heart Lab staff and graduate students facilitated a cardiac anatomy demonstration for employees of the Children's Heart Clinic on June 30, 2010.
Ryan Goff and Jules Eggum at the cardiac anatomy demo
Jules Eggum demonstrates the Human Heart Atlas
A manuscript written by Maneesh Shrivastav (PhD, 2007) and Paul Iaizzo was recently published in Computurs in Biology and Medicine. The complete citation: An interactive graphical user interface for comprehensive analysis of human and swine cardiac monophasic action potential. Comput Biol Med 2009 Dec;39(12):1105-16. Congratulations!
Bill Hudson, WCCO reporter, will be flying to Washington DC on June 17th to accept the National Michael E. Debakey Journalism Award for his TV news story on bear research that was featured in March--"Black Bear Research May Revolutionize Medicine."
Mark Marshall successfully defended his master thesis "The effects of temperature on cardiac pacing threshold" on May 26th. Great job, Mark!
The manuscript "Equivalent moving dipole localization of cardiac ectopic activity in a swine model during pacing" will be published in Transactions on Information Technology in Biomedicine in 2010. Congrats to co-authors Dakun Lai, Chenguang Liu, Michael Eggen (PhD, 2010), Paul Iaizzo, and Bin He.
Robin Brusen successfully defended his masters thesis "Continuous hypothermic perfusion of large mammalian hearts, followed by in vitro Langendorff reanimation," on May 14th. Robin is part of the MD/MS program here at the U of MN, and will be rejoining his medical school colleagues in June. Congratulations Robin!
Officials from Medtronic and the University finalized signatures on the research contract extension on April 26th, enabling the lab to continue our Visible Heart research for the next 5 years. TIME TO CELEBRATE!!
The Visible Heart Lab was featured in a front page article, "U Researchers Get Inside Look at Heart," of the Minnesota Daily on April 29, 2010. Get in line for Chris Rolfes' autograph!
Mike Bateman attended the Experimental Biology 2010 annual meeting (April 24-28) in Anaheim, CA to present his poster "A detailed anatomical study of the papillary muscles and chordae tendineae of the left ventricule in perfusion fixed human hearts."
In collaboration with other researchers, our lab has recently published several manuscripts:
The manuscript "Freeze–Thaw Induced Biomechanical Changes in Arteries: Role of Collagen Matrix and Smooth Muscle Cells" was published in the March 2010 issue of the Annals of Biomedical Engineering. Congrats to co-authors Ranjit Venkatasubramanian, Wim Wolkers, Mithun Shenoi, Victor Barocas, Daniel Lafontaine, Charles Soule, Paul Iaizzo, and John Bischof!
Bear researchers Dave Garshelis, Tim Laske (PhD, 2004), and Paul Iaizzo were featured in WCCO's story "Black Bear Research May Revolutionize Medicine" on March 9th. Here's an excerpt from the story: Researchers are discovering that unique properties in the bear's blood plasma or serum likely protects the animal's organs and muscle tissue from a lack of oxygen. It's that lack of nourishment and oxygen in the blood that leads to heart and muscle damage. If similar "plasma fractions" or synthetic compounds can be applied for medical use in humans, it would mean quicker recoveries from surgery and a greatly expanded number of heart transplants.
The abstract entitled "Intramural Mapping of Ventricular Activation in the Swine Heart from Body Surface Potential Measurements" was accepted for a poster presentation at the Heart Rhythm Society annual scientific meeting in 2010. Congrats to co-authors Chenguang Liu, Paul Iaizzo, and Bin He.
A second abstract, "The Use of Gut Interstitial Cells of Cajal for Cardiac Conduction Repair," was also accepted as a poster presentation at Heart Rhythm. Co-authors include Yong-Fu Xiao, Alena Nikolskaya, Eric Richardson (PhD, 2008), and Paul Iaizzo. Great job!
Paul Iaizzo and Dr. Mike Loushin received a Center for Excellence in Critical Care Seed Grant for the project "The non-invasive assessment of involuntary muscle forces and muscle diameters in critically ill ICU patients: Correlations with extubation criteria." Congratulations!
Uzma Usmani's (LSSURP, 2009) abstract "Cardioprotective Pretreatment for Global Ischemia of Isolated Swine Hearts" was approved for presentation at the NCUR (National Conference for Undergraduate Research) Conference in Montana in April. Congratulations!
Paul Iaizzo traveled to Fort Lauderdale in January for the NATCO Symposium (Organization for Transplant Professionals). While there, Paul facilitated three 90-minute rotations on "The Visible Heart: Echocardiography and Angiography Application in the Donor Heart."
Paul Iaizzo co-created the program and facilitated "The Medical Device Development Process: Innovations Associated with Cardiovascular Therapies," in conjunction with the Innovations in Cardiovascular Interventions (ICI) 2009 Meeting in Israel on December 7-8.
Darryl Finkton (LSSURP Student, 2007) just learned that he won a Rhodes Scholarship and will be attending Oxford to study for an MSc in Global Health and an MBA. Congratulations and good luck, Darryl!
Congratulations to co-authors Mike Eggen (PhD, 2009), Mike Bateman, Chris Rolfes, Steve Howard, Cory Swingen, and Paul Iaizzo on the acceptance of their manuscript "MRI assessment of pacing induced ventricular dyssynchrony in an isolated human heart" for publication in an upcoming issue of Journal of Magnetic Resonance Imaging (Clinical Note).
Uzma Usmani's summer LSSURP research project "Cardioprotective Pretreatment for Global Ischemia of Isolated Swine Hearts" has been accepted for a poster presentation at the American Biomedical Research Conference for Minority Students in November. Congrats Uzma!
Mike Eggen successfully defended his PhD thesis "Heart failure and associated structural and functional remodeling: assessment employing various magnetic resonance imaging methodologies" on September 28th. Congratulations Dr. Eggen!
Maneesh Shrivastav (PhD, 2007) and Paul Iaizzo will have their manuscript "An interactive graphical user interface for comprehensive analysis of human and swine cardiac monophasic action potential" published in an upcoming issue of Computers in Biology and Medicine. Congratulations!
Mike Bateman passed his oral preliminary exam entitled "The importance of the electrical conduction system and valve anatomy in the development of transcatheter delivered valve therapies" on September 16th. Congratulations Mike!
Congratulations to Chris Rolfes who passed his oral preliminary exam on September 15th (Title: Intrapericardial delivery of cardioprotective agents for global ischemia). Great job, Chris!
Paul Iaizzo attended the IEEE Engineering in Medicine and Biology Society 2009 conference (Minneapolis, MN, September 2-6) where he presented and also chaired Theme 5 of the technical program "Cardiovascular & Respiratory Systems Engineering."
Thanks to Cori Russell and Gary Williams for organizing the Visible Heart booth at the Minnesota State Fair on Thursday, September 3rd. The booth was expertly manned by students Steve Howard, Brian Chan, Devon Hutton, Cori Russell, and John Aho (Chicago Medical School) from our lab, in addition to second year University of Minnesota Medical students Megan Rooney, Arney Abcejo, Joe Schmidt, and John Schomberg. What a great team!
Cori Russell and Steve Howard
Visible Heart Booth at the Minnesota State Fair
Congratulations to Mark Marshall, Dr. Ken Liao, Dr. Mike Loushin, and Paul Iaizzo on the publication of their manuscript "The effects of temperature on cardiac pacing thresholds" in Pacing and Clinical Electrophysiology (in press, 2009).
LSSURP students Uzma Usmani and Jerfiz Constanzo presented their research posters at the Life Sciences Summer Undergraduate Research Programs Poster Symposium on August 7, 2009. Uzma, from the New York Institute of Technology, presented on "Cardioprotective pretreatment for global ischemia of isolated swine hearts," and Jerfiz, from Universidad Metropolitana in Puerto Rico, presented "Improved methodologies to perform DTI imaging of perfusion fixed large mammalian hearts within a 3 Tesla MRI unit: minimization of motion artifacts." Great job, Uzma and Jerfiz!
Paul Iaizzo recently published the following two manuscripts with collaborating co-authors:
1) Global electrophysiological and hemodynamic assessment of ventricular pacing employing non-contact mapping, Journal of Interventional Cardiac Electrophysiology, Co-authors Nick Skadsberg (PhD, 2004), Trent Fischer, and Dan Kaiser.
2) Radio frequency heating at 9.4T (400.2 MHz): In vivo thermoregulatory temperature response in swine, Magnetic Resonance in Medicine, Co-authors D Shrivastava, T Hanson, J Kulesa, L DelaBarre, and JT Vaughan.
Three abstracts were recently published in the June 2009 Journal of Medical Devices:
1) Visualization of coronary artery bypass grafts and coronary artery stents in re-animated and perfusion fixed human hearts; Co-authors Mike Bateman, Chris Rolfes, and Paul Iaizzo.
2) Visualization and hemo-dynamic evaluation of edge-to-edge mitral valve repair within reanimated swine hearts; Co-authors Mike Bateman, Jason Quill, James St. Louis, and Paul Iaizzo.
3) A novel combination therapy for post-operative arrhythmias; Co-authors Eric Richardson, Bryan Whitson, and Paul Iaizzo.
Charles Soule and Paul Iaizzo, along with co-authors Oliver Bandschapp, Hans Ginz, Terry Girard, and Albert Urwyler, will have their manuscript "In vitro effects of propofol and volatile agents on pharmacologically induced chloride channel myotonia" in the September 2009 issue of Anesthesiology. Well done!
The manuscript "Effect of left ventricular lead positions and coronary venous microanatomy on pacing parameters" was accepted for publication in the Journal of Electrocardiology. Kudos to co-authors Sara Anderson and Paul Iaizzo.
Marc Steckler presented his Masters Plan B Project (Muscle force assessment system: adductor pollicis measurement device) on May 15th, earning his Masters degree in Biomedical Engineering. Congrats, Marc!
Jason Quill defended his PhD thesis (Applications of the Visible Heart for Cardiac Valve Repair and Replacement Devices) to committee members, family, and friends on May 7th. Congratulations Dr. Quill!
Congratulations to Eric Richardson who successfully defended his PhD thesis (Intrapericardial delivery of anti-arrhythmic agents) on May 5th. Way to go, Eric!
Chris Rolfes was awarded a one year graduate research assistant appointment on the NRSA-NIAMS Training Program in Muscle Research grant starting May 1, 2009. Congrats Chris!
Eric Richardson won an award for his presentation "A Novel Combination Therapy for Post-Operative Atrial Fibrillation" in the Three-in-Five Competition at the Design of Medical Devices Conference (Minneapolis, MN, April 14-16, 2009). This competition required all participants to summarize their research on only three slides and present in 5 minutes or less. As one of three award winners, he will expand his one-page abstract to a two-page Technical Brief which will be published in the Journal of Medical Devices. Well deserved, Eric!
The manuscript "Not every bulb is a rose: a functional comparison of bulb suction devices" was accepted for publication in the Journal of Surgical Research. Congrats to co-authors Bryan Whitson, Donavon Hess, Eric Richardson, and Paul Iaizzo!
A Visible Heart Laboratory image will be featured on the cover of the Journal of Thoracic and Cardiovascular Surgery in May 2009. Congrats to Jason Quill, Alex Hill (PhD, 2003), Tim Laske (PhD, 2004), Ottavio Alfieri, and Paul Iaizzo, co-authors of "Mitral valve anatomy revisited"!
A few months ago, Paul Iaizzo was interviewed about Technological and Medical Advancements at the University of Minnesota; this interview (U.S. History: 1865 to Present, Part 6) can be found on http://www.researchchannel.org/prog/displayevent.aspx?rID=28389&fID=5955.
Paul Iaizzo and Tim Laske (PhD, 2004) were featured in Scientific American's "10 Lessons Medicine Can Learn from Bears." Check it out at: http://www.sciam.com/article.cfm?id=bear-hibernation-science
The 2nd Annual Bakken Surgical Device Symposium "Cardiac Valves: Past, Present, and Future" was held at the Mayo Auditorium on December 8th and 9th, 2008. Sessions focused on mechanical and tissue heart valves, as well as device development, techniques, and technology. Thanks to Dick Bianco and Steff Yorek for planning an incredible event!
Dr. Earl Bakken welcoming
Dick Bianco facilitating panel discussion "Cardiac Surgeons and Cardiologists on Future Directions in Cardiac Valve Replacement"
Nick Skadsberg (PhD, 2004), Paul Iaizzo, and Jason Quill attended the AHA conference in New Orleans (November 9-12, 2008). While there, they manned a hands-on booth featuring swine and human hearts, as well as the Atlas of Human Cardiac Anatomy.
Jason Quill, Paul Iaizzo, and Nick Skadsberg
Medtronic/Visible Heart Booth
Congratulations to Sally Anzelc on earning her Masters degree in Biomedical Engineering! Sally presented her Masters Plan B project "Cardiac Comparatiave Imaging at the Visible Heart Lab" on November 25, 2008.
The abstract "Functional Comparison of Bulb Suction Devices" was accepted as a "Quick-Shot Mini Oral" presentation at the 4th Annual Academic Surgical Congress (Fort Myers, Feb. 3-6, 2009). Congratulations to UM collaborators Bryan Whitson, Eric Richardson, Paul Iaizzo, and DJ Hess!
Senior PhD graduate students Mike Eggen, Jason Quill, and Eric Richardson attended the annual Transcatheter Cardiovascular Therapeutics (TCT) conference in Washington DC (October 12-17). This conference highlighted the latest developments in invasive and noninvasive cardiovascular care.
The Medical Devices Center (MDC) in the Institute for Engineering in Medicine (IEM) selected the grant application "Development of a composite drug delivery and electrical sensing/stimulating implantable catheter" for funding this year. Congratulations to co-investigators Brian Whitson, Eric Richardson, and Paul Iaizzo!
The manuscript "Mitral Leaflet Anatomy Revisited" was accepted for publication by The Journal of Thoracic and Cardiovascular Surgery. Congratulations to co-authors Jason Quill, Alex Hill (PhD, 2003), Tim Laske (PhD, 2004), Ottavio Alfieri, and Paul Iaizzo.
The Visible Heart Lab hosted Dr. Earl Bakken for a visit on September 2nd during which faculty, staff, and graduate students had the opportunity to showcase their various research projects. Research collaborators from Medtronic were also on hand to describe their projects and their relationship to the Visible Heart Lab.
Graduate students from the Visible Heart Laboratory manned an educational booth at the Minnesota State Fair on August 28th as part of the University of Minnesota's Academic Health Center (AHC) Day. Using heart models, images from the Atlas of Human Cardiac Anatomy, and preserved human hearts, Eric Richardson, Mike Eggen, and Meredith Thompson fielded questions from fairgoers on cardiac anatomy. The goal was to get people excited about science, medicine, and biomedical engineering. Thanks also to Gary Williams for leading this effort and setting up the booth!
Rebecca Li co-authored an article "Mechanical Stress: An Independent Determinant of Early Bioprosthetic Calcification in Humans" that was recently published in The Annals of Thoracic Surgery. Other co-authors include Kenneth Liao, Ranjit John, Devesh Amatya, Lyle Joyce, Soon Park, Richard Bianco, and R. Morton Bolman. Congratulations!
The article "Novel visualization of intracardiac pacing lead extractions: methodologies performed within isolated canine hearts" was accepted for publication in the Journal of Interventional Cardiac Electrophysiology. Congratulations to co-authors Charles J. Love, Sarah Ahlberg (PhD, 2007), Medtronic research collaborators Prasanga Hiniduma-Lokuge and Scott Brabec, and Paul Iaizzo!
Paul Iaizzo attended the Cardiostim 2008 Meeting (June 17-20, 2008) in Nice, France where he facilitated a hands-on demonstration promoting research from the Visible Heart Lab.
Paul Iaizzo attended the annual scientific meeting of the International Society for Minimally Invasive Cardiothoracic Surgery (ISMICS) on June 11-14, 2008 in Boston. While there, he presented the paper "Comparative Imaging of Devices and Procedures for the Treatment of Structural Heart Disease" as a Mini Presentation; this paper was co-authored by Tim Laske (PhD, 2004), John Liddicoat MD, and Paul.
Congratulations to Sara Overgaard who successfully defended her Masters thesis (Design and Use of an Isolated Heart-mounting Fixture for the Visible Heart Apparatus) on May 21st.
Paul Iaizzo was recently featured on ReachMD (Radio XM157) in relation to his research on opioids, fish oils, and hibernating bears. Program Description: How do opioids, fish oils and hibernating bears relate to the study of heart disease? It’s a fascinating correlation, currently under the meticulous study of Paul Iaizzo, PhD, professor of anesthesiology, physiology, and surgery, and the principal investigator in the Visible Heart Laboratory at the Medical School at the University of Minnesota. Dr. Iaizzo joins host Dr. Matthew Sorrentino to detail the remarkable cardioprotective possibilities of an array of hormones found in hibernating bears, and the hormonal interactions with morphine, as well as a separate but related investigation into targeted deliveries of omega-3s. (http://www.reachmd.com/xmsegment.aspx?sid=2953)
The manuscript "Venous valves within left coronary veins" was accepted for publication by the Journal of Interventional Cardiac Electrophysiology. Congrats to co-authors Sara Anderson, Jason Quill, and Paul Iaizzo.
Paul Iaizzo and Nick Skadsberg (PhD, 2004) represented the Visible Heart Lab and Medtronic at the Heart Rhythm Society Conference (May 14-17, 2008) in San Francisco, where they facilitated an interactive demonstration for attendees.
Eric Richardson was awarded with the University of Minnesota Graduate School Doctoral Dissertation Fellowship for his translational research on evaluating drugs, delivery systems, and conditions that combine to make promising new therapies available for patients with heart rhythm disorders. Terrific job, Eric!
Sara Anderson accepted a position with Covidien in Boulder, Colorado as a R&D Engineer. She will begin in late May or early June. Congratulations Sara!
Sara Overgaard accepted a position as Reliability Engineer in the CRDM Division of Medtronic, Inc. Congrats Sara!
Congratulations to Sara Anderson, Alex Hill (PhD, 2003), and Paul Iaizzo who just learned that their manuscript "Microanatomy of human left ventricular coronary veins" was accepted for publication in Anatomical Record! Great news!!
Sara Anderson successfully defended her PhD thesis "Effects of pacing lead position and cardiac anatomy on left ventricular venous pacing" on Friday, April 11, 2008. Well done, Sara!
Paul Iaizzo and Alex Hill (PhD, 2003) represented the Visible Heart Laboratory and Medtronic, Inc. at the ACC Annual Meeting in Chicago (March 29-April 1, 2008), where they facilitated an interactive display for ACC attendees.
March 5, 2008
Kudos to Yong-Fu Xiao, Daniel Sigg (post-doc, 1999), Mike Ujhelyi, Josh Wilhelm, Eric Richardson, and Paul Iaizzo on the acceptance of their manuscript "Pericardial delivery of Omega-3 fatty acid: A novel approach to reduce myocardial infarct sizes and arrhythmias" for publication in AJP: Heart and Circulatory Physiology.
February 5, 2008
Paul Iaizzo recently accepted a position in the Engineering in Medicine and Biology Society (EMBS); effective immediately, he is the new IEEE Chair of the Technical Committee on Cardiopulmonary Systems. Congrats Paul!
February 5, 2008
Congratulations to Tim Laske (PhD, 2004) and Alex Hill (PhD, 2003) who were approved as Adjunct Professors in the Department of Surgery, University of Minnesota, in January.
February 5, 2008
Paul Iaizzo traveled to Fort Lauderdale, Florida for the Society for Thoracic Surgeons Conference last month (January 27-30, 2008). While there, he represented the Visible Heart lab at an interactive display for conference participants.
February 5, 2008
Mike Eggen passed his oral prelims with flying colors on Friday, February 1st. Congrats and good luck, Mike!
Our lab hosted the 1st Annual Bakken Surgical Device Symposium on December 13th, 2007 at the Mayo Auditorium. The scientific program, entitled "The Pacemaker: Past, Present, and Future" featured several speakers including: Earl Bakken (founder of Medtronic, Inc. and inventor of the battery-powered pacemaker), Vincent Gott MD (Johns Hopkins Medical Institute), David Rhees PhD (Bakken Museum), Samuel Hunter MD (retired cardiac surgeon), Walter Olson (VP Research, CRDM Medtronic, Inc.), David Benditt MD (Cardiology, U of MN), Dusan Kocovic MD (Lankenau Hospital), Mike Hess (VP Product Planning, CRDM Medtronic, Inc.), Kenneth Liao MD (Cardiac Surgery, U of MN), Bin He PhD (Biomedical Engineering, U of MN), and Eduardo Marban (Cedars-Sinai Heart Institute). The second annual Bakken Surgical Device Symposium is scheduled for December 2008 and will focus on heart valves.
November 19, 2007
Congratulations to co-authors Paul Iaizzo, Alex Hill (PhD, 2003), and Tim Laske (PhD, 2004) on the acceptance of their manuscript "Cardiac device testing enhanced by simultaneous imaging modalities: the Visible Heart®, fluoroscopy, and echocardiography" to the Expert Review of Medical Devices.
November 19, 2007
At the 2007 American Heart Association Scientific Sessions, Paul Iaizzo and Sara Anderson guided an interactive display allowing interested participants to see and feel real human and animal hearts in various disease stages. This was part of Medtronic's Mobile Education Unit, a highlight at AHA's Emerging Technologies/Hands-On Learning Showcase.
November 7, 2007
The manuscript "Estimation of global ventricular activation sequences by noninvasive 3-dimensional electrical imaging: validation studies in a swine model during pacing" was accepted for publication in the Journal of Cardiovascular Electrophysiology. Co-authors include: Chenguang Liu, Nick Skadsberg (PhD, 2004), Sarah Ahlberg (PhD, 2007), Cory Swingen, Paul Iaizzo and Bin He. Congratulations!
November 7, 2007
Paul Iaizzo and Sara Anderson attended the American Heart Association Scientific Sessions 2007 in Orlando, Florida (November 4-6). Medtronic's Mobile Education Unit was one of the major highlights of AHA's Emerging Technologies/Hands-On Learning Showcase (see picture below). Paul and Sara guided an interactive display allowing interested participants to see and feel real human and animal hearts in various disease stages.
October 3, 2007
Congratulations to co-authors Sarah Ahlberg (PhD, 2007), Arthur Yue. Nick Skadsberg (PhD, 2004), Paul Roberts, Paul Iaizzo, and John Morgan on the acceptance of their manuscript "Investigation of pacing site-related changes in global restitution dynamics by noncontact mapping" to Europace.
September 11, 2007
Kudos to Eric Richardson who passed his oral preliminary examination on September 11th. His presentation was entitled "Intrapericardial delivery of omega-3 fatty acids."
September 11, 2007
Co-authors Jason Quill, Tim Laske (PhD, 2004), Alexander Hill (PhD, 2003), Philipp Bonhoeffer MD, and Paul Iaizzo just learned that their manuscript "Direct visualization of a transcatheter pulmonary valve implantation within the Visible Heart®--A Glimpse into the Future" will be published in the Images section of Circulation. Terrific work!
September 11, 2007
The manuscript "Single-site ventricular and biventricular pacing: investigation of latest depolarization strategy" was accepted for publication in Europace. Congrats to the co-authors Mike Kimmel (PhD, 2007), Nick Skadsberg (PhD, 2004), Charles Byrd MD, Jay Wright MD, Tim Laske (PhD, 2004), and Paul Iaizzo!
September 10, 2007
Vince Splett successfully defended his master's thesis (Dual-chamber coupled pacing in a pig model effects on sympathetic tone and plasma renin activity and effects of RV extrastimulus site) on Friday, September 7th. Great job, Vince!!
September 5, 2007
Paul Iaizzo was named the Associate Director of Education for the Institute for Engineering in Medicine (formerly Biomedical Engineering Institute) at the University of Minnesota. This institute unites Medical School and Engineering faculty and community counterparts in creating new medical devices, solving clinical problems, and promoting collaboration between the University and industry. Congratulations Paul!
September 5, 2007
Congratulations to Jason Quill who passed his oral preliminary examination (Structural heart disease investigations using the Visible Heart) on August 28th!
August 21, 2007
The manuscript "Venous Valves: Unseen Obstructions to Coronary Access" was accepted for publication in Journal of Interventional Cardiac Electrophysiology. Great job co-authors Sara Anderson, Alex Hill (PhD, 2003) and Paul Iaizzo!
July 23, 2007
Paul Iaizzo facilitated a workshop, The Visible Heart: Functional Human Cardiac Anatomy, in the Josephson and Wellens How to Approach Complex Arrhythmias for EP Fellows program on Friday, July 20th in Boston, MA. Sara Anderson was a TA for the anatomy demonstration as well.
July 19, 2007
Congratulations to co-authors Sarah Ahlberg (PhD 2007), Nathan Grenz, Daniel Ewert, Paul Iaizzo, and Dr. Lawrence Mulligan on the acceptance of their manuscript to Cardiovascular Engineering: Effect of pacing site on systolic mechanical restitution curves in the in vivo canine model, in press 2007.
June 7, 2007
PACE accepted the manuscript "Variation in pacing impedance: impact of implant site and measurement method" for publication. Congratulations to co-authors Sara Anderson, Nick Skadsberg (PhD, 2004), Tim Laske (PhD, 2004), Dr. David Benditt, and Paul Iaizzo!
June 7, 2007
Maneesh Shrivastav's (PhD, 2007) paper entitled "Discrimination of ischemia and normal sinus rhythm for cardiac signals using a modified k means clustering algorithm" was accepted for presentation at the 29th International Conference of the IEEE Engineering in Medicine and Biology Society in conjunction with the Biennial Conference of the French Society of Biological and Medical Engineering (SFGBM) to be held in Lyon, France from August 23-26, 2007. Great work, Maneesh!
March 17, 2007
Co-authors Hans Ginz, Paul Iaizzo, Albert Urwyler, and Hans Pargger recently learned that their manuscript "Use of non-invasive stimulated muscle force assessment in long-term critically ill patients: a future standard in the intensive care unit?" will be published in Acta Anaesthesiologica Scandinavica. Congratulations to all!
April 27, 2007
Congrats to Maneesh Shrivastav who topped off a wonderful week in the lab (three PhD degrees this week!!) by successfully defending his PhD thesis "The cardiac potential: applications in myocardial ischemia" on Friday, April 27th. Wonderful accomplishment, Maneesh!
April 27, 2007
Kudos to Sarah Ahlberg who earned her PhD degree after defending her thesis "Investigation of the influence of long- and short-term cardiac pacing from alternate sites on the electrical and mechanical performance of the heart in the in vivo animal model" on Wednesday, April 25th. Great job, Sarah!
April 24, 2007
Michael Kimmel successfully defended his PhD thesis "Swine models for study and optimization of biventricular pacing therapies as treatments for heart failure" on Tuesday, April 24th. Congratulations Mike!
April 19, 2007
Paul Iaizzo was presented with a commemorative silver plate on April 19th, 2007 to acknowledge his many years of leadership in co-directing the Design of Medical Devices conference at the University of Minnesota. Thanks for all your hard work, Paul!
March 26, 2007
Congratulations to Sarah Frommer who successfully defended her PhD thesis "Investigating the use of multipotent adult progenitor cells for treatment of Duchenne Muscular Dystrophy: a translational approach" on Friday, March 23rd. Way to go, Sarah!
Jason Johnson will present a poster on perioperative hypothermia and the Hot Dog Warming System at the International Anesthesia Research Society 81st Clinical & Scientific Congress in Orlando, Florida (March 23-27, 2007).
Paul Iaizzo was invited to present at the Annual Conference of the Idaho Society of Anesthesiologists in Sun Valley, Idaho (March 3-4, 2007). His presentations were "Malignant Hyperthermia: a current view” and “Translational research: from bear den to bedside.”
January 17, 2007
Congratulations to Tom Bischoff, Marty Martens, Matt Adams (Masters, 2005), Bill Gallagher, and Paul Iaizzo on the acceptance of their manuscript "Measurement of impact loads applied to an implant drug pump connector in a porcine cadaver specimen" for publication in the Journal of Medical Devices.
Hats off to course director and lecturer, Paul Iaizzo, for yet another successful Advanced Cardiac Physiology and Anatomy course in January. Feedback from students has been very positive. Also participating in the course were lecturers Daniel Sigg (post-doc, 1999), George Bojanov (post-doc, 2000), Alex Hill (PhD, 2003), Tim Laske (PhD, 2004), Sarah Ahlberg (current PhD candidate), as well as teaching assistants Jason Quill and Eric Richardson.
December 12, 2006
Paul Iaizzo and several graduate students participated in the annual LifeScience Alley (previously Medical Alley) Conference at the River Centre (St. Paul) on Wednesday, December 6th. Thanks to everyone who presented posters, and CONGRATULATIONS to Sara Anderson who won the Lillehei Heart Institute Award for her poster entitled "Microanatomy of the Left Ventricular Coronary Veins" (Cellular Bioengineering category).
December 7, 2006
The Visible Heart Laboratory was honored to host a visit by Earl Bakken on Thursday, December 7th. During the visit, Mr. Bakken was able to observe an in vitro swine experiment and discuss research projects with various investigators and clinicians.
October 24, 2006
Paul Iaizzo is making a presentation at the Transcatheter Cardiovascular Therapeutics conference in Washington DC on Thursday, October 26th.
October 24, 2006
Sara Anderson successfully passed her oral preliminary examination on Friday, October 20th. The title of Sara's presentation was "Device-Tissue Interactions: The Relationship Between Pacing Lead Orientations and Cardiac Anatomy." Good job, Sara--we're proud of you!!
October 23, 2006
Visible Heart staff and students, along with Alex Hill (PhD, 2003) from Medtronic, Inc., manned a table at the 42nd annual Nobel Conference hosted by Gustavus Adolphus College in St. Peter, Minnesota (October 3-4, 2006). The topic of the conference was "Medicine: Prescription for Tomorrow." Representing the Visible Heart Lab were Paul Iaizzo, Eric Richardson, and Sarah Ahlberg.
October 23, 2006
Sara Anderson recently presented her research on "Micro-Anatomy of the Left Ventricular Coronary Veins" at the 25th Medtronic Science and Technology internal conference. Approximately 40 abstracts were chosen to be presented as one minute orals during this conference. Congrats Sara!
October 18, 2006
The manuscript "Dynamic obstruction to coronary sinus access: The Thebesian Valve" was published in the October 2006 issue of Heart Rhythm (Image section). One of the figures was prominently featured on the cover of the journal! Great job, Alex Hill (PhD, 2003), Sarah Ahlberg, Dr. Bruce Wilkoff, and Paul Iaizzo (co-authors).
October 18, 2006
Jason Quill attended the BMES Annual Meeting (October 11-14, 2006) in Chicago with representatives from the University's Biomedical Engineering Institute. While there, he promoted the Visible Heart lab and our resesarch collaboration with Medtronic, Inc.
September 28, 2006
Paul Iaizzo will be recognized tomorrow at the Scholars Walk Dedication (between McNamara Alumni Center and Church Street on the East Bank). Paul was a recipient of the Award for Outstanding Contributions to Graduate and Professional Education in 2001-02; this award earned Paul the distinction as "Distinguished Teacher" at the University of Minnesota. The Scholars Walk honors great research and academic accomplishments of the U's faculty and students; individual monuments recognize Nobel and Pulitzer Prize winners, Rhodes, Truman, and Marshall Scholars, members of top academic academies, as well as Distinguished Teachers. Congratulations Paul!!
September 19, 2006
Maneesh Shrivastav's paper "In vivo cardiac monophasic action potential recording using electromyogram needles" was recently accepted for lecture presentation at the IEEE Biomedical Circuits and Systems conference featuring healthcare technology (November 29-December 1, 2006; The British Library, London). Congrats Maneesh!
September 18, 2006
Jason Quill recently returned from the HFSA conference (Seattle, September 10-13, 2006) where he presented a poster entitled "Comparative anatomy of aortic and mitral valves in human, ovine, canine and swine hearts." Co-authors included Alex Hill (PhD, 2003) and Paul Iaizzo.
September 8, 2006
Kudos to Sarah Ahlberg, Crystal Ripplinger, Nick Skadsberg (PhD, 2004), Paul Iaizzo, and Larry Mulligan! Their manuscript entitled "Effects of pacing rate on mechanical restitution within the in vivo canine heart: Study of the force-frequency relationship" was just accepted for publication in the Journal of Cardiovascular Electrophysiology. Good work, team!
August 22, 2006
Justin Schaffer (BMEn, 2006) successfully defended his Plan B masters research project entitled "Potential benefits of DHA on Ischemic Preconditioning of Isolated Myocardial Tissue" on Friday, August 18th. Best wishes to Justin as he begins medical school at Johns Hopkins later this month.
August 15, 2006
Congrats to Kate Chromy (DPT, 2002), Mike Carey (DPT, 2002), Kristopher Balgaard (DPT, 2002), and Paul Iaizzo on the publication of their article entitled "The potential use of axial spinal unloading in the treatment of adolescent idiopathic scoliosis: A case series." This article will be published in the Archives of Physical Medicine and Rehabilitation later in 2006.
July 25, 2006
The Biomedical Engineering Institute of the University of Minnesota has awarded funding to three projects in our lab: 1) Paul Iaizzo's Cardiovascular Physiology Interest Group ($45,000); 2) Sarah Ahlberg's research on "Global and regional investigation of pacing site on electrical restitution in the intact swine heart" ($16,000); and Mike Eggen's "MRI compatible Langendorff perfusion apparatus" project ($6,000). Congratulations to all!
June 23, 2006
The lab was honored to host a visit from Mr. Earl Bakken on Friday, June 23rd. Visible Heart students and staff had the opportunity to showcase their research. Their presentations were followed by a brief ceremony to commemorate the unique collaboration between Dr. C. Walton Lillehei and Earl Bakken, a collaboration that gave birth to the cardiac pacemaker, helped to create the field of biomedical engineering, and spawned the medical device industry in the state of Minnesota.
Daniel Sigg (PhD, 2001) and Paul Iaizzo had a manuscript accepted by the European Journal of Pharmacology: In vivo versus in vitro comparison of swine cardiac performance: Induction of cardiodepression with halothane. Kudos to Daniel and Paul for their persistent efforts in resubmitting this manuscript!
Students in the Visible Heart lab presented nine posters at the Design of Medical Devices conference in Minneapolis (April 19-21, 2006). Judges awarded cash prizes to the following students in the lab: 1) Sarah Ahlberg (Effects of Pacing Rate on Mechanical Restitution within the In Vivo Canine Heart: Study of the Force-Frequency Relationship), 3rd place in the cardiac category; 2) Sarah Frommer (A Novel In Vivo Force Assessment Device to Detect Differences in Normal and Injured Murine Hindlimb Force), 1st place in the devices category; and 3) Sarah Ahlberg (Determination of Pacing Site Effects on Ventricular Repolarization by Non-Contact Mapping), 3rd place in devices category. Thanks to all the students who presented posters, and congratulations to the first and third place finishers!
Congratulations to Dan Geoffrion and Andy McCullough (student volunteers from Breck High School, 2005) who competed at the Minnesota State Science Fair with their research project "Objective tests of gastocnemius muscle response for Duchene's Muscular Dystrophy." They took 1st place for their paper/PowerPoint presentation and were invited to national competition. In addition, they were chosen as the alternate to participate in the International Science & Engineering Fair (ISEF) in the poster competition. Great work, Team Dandy!
The abstract "Voltage-dependent hysteresis of human pacemaker channels expressed in HEK293 cells" was accepted for presentation at the 28th Annual International Society for Heart Research American Section Meeting in Toronto (June 14-16, 2006). Authors are: Yong-Fu Xiao, Joshua Wilhelm, Erica TenBroek, Paul Iaizzo, and Daniel Sigg (PhD, 2001). Congratulations!
Yong-Fu Xiao reported that the manuscript "Electrophysiological Characterization of Murine HL-5 Atrial Cardiomyocytes" was accepted for publication in the American Journal of Physiology-Cell Physiology. Additional co-authors include: Erica TenBroek, Joshua Wilhelm, Paul Iaizzo, and Daniel Sigg (PhD, 2001). Great work!
The manuscript "Dynamic Obstruction to Coronary Sinus Access: The Thebesian Valve" was accepted for publication in Heart Rhythm's IMAGES section. Congrats to Alex Hill (PhD, 2003), Sarah Ahlberg, Dr. Bruce Wilkoff, and Paul Iaizzo!
Congratulations to Sara Anderson who earned her Masters degree on February 28th after successfully defending her thesis "Variation in pacing impedance: Impact of implant site, measurement method, morphology and time post-implant."
Paul Iaizzo just learned that three manuscripts
have been accepted for publication in 2006, including:
* Snedeker JG, Barnstuble BB (MS, 2002), Iaizzo PA, Farshad M, Niederer P, Schmidlin FR: A comprehensive renal injury concept based on a validated finite element model of the human abdomen. Journal of Trauma, Injury, Infection, and Critical Care (in press) 2006.
* Lohuis T, Harlow HJ, Beck TdI, Iaizzo PA: Hibernating bears conserve muscle strength and maintain fatigue resistance. Physiological and Biochemical Zoology (in press) 2006.
* Sola S, Garshelis DL, Amaral JD, Noyce KV, Coy PL, Steer CJ, Iaizzo PA, Rodrigues CMP: Plasma levels of ursodeoxycholic acid in black bears, Ursus americanus: seasonal changes. Comparative Biochemistry and Physiology (in press) 2006.
The Heart Rhythm Society accepted abstracts that our researchers
will present at the upcoming annual scientific meeting in Boston,
MA (May 17-20, 2006):
1. Global changes of restitution dynamics during right ventricular apical and septal pacing (oral presentation). Co-authors are Sarah Ahlberg, Nick Skadsberg (PhD, 2004), Arthur Yue, Paul Roberts, John Morgan, and Paul Iaizzo.
2. Pacing induced dysynchrony of left-right interventricular coupling in the normal heart (poster presentation). Co-authors include Trent Fischer, Mike Kimmel, Paul Iaizzo, and Dan Kaiser.
3. The effects of temperature modulation on cardiac pacing stimulation threshold (poster presentation). Co-authors include Mark Marshall, Theresa Rosendahl, Kenneth Liao, Michael Loushin (1993-8 volunteer/research assistant, 2001-2 post doc), and Paul Iaizzo.
Congratulations and good luck to all the authors!!
The manuscript "Anatomical Dependence of Intracardiac Stimulation Electrodes on HIS Bundle and Interventricular Septal Pacing" has been accepted for publication by PACE. Congrats to co-authors Tim Laske (PhD, 2004), Nick Skadsberg (PhD, 2004), Alex Hill (PhD, 2003) and Paul Iaizzo!
On January 29, 2006, Paul Iaizzo and Tim Laske (PhD, 2004) will be featured on TechTalk in a segment about Medical Technology and Devices. This interview will air at 9:00pm on TPT MN Channel 17 Twin Cities (see http://techtalk.umn.edu/schedule).
In December 2005, Tim Laske (PhD, 2004) was honored by induction into the Bakken Society, a prestigious honorary fellowship dedicated to recognizing individuals who have distinguished themselves in furthering the technical and scientific progress of Medtronic, Inc. The Visible Heart Laboratory celebrated Tim's accomplishment with a "surprise" dinner on December 10th. Congratulations, Tim!
Paul Iaizzo coauthored an article "Decreased isometric skeletal muscle force in critically ill patients" with several research colleagues at University Hospital in Basel, Switzerland. The article was published in Swiss Medical Weekly (135: 555-561, 2005). Nice going, Paul!
Tim Laske (PhD 2004), Hank Harlow, John Werder, Mark Marshall and Paul Iaizzo recently had a manuscript accepted in the Journal of Biomechanical Engineering: "High capacity implantable data recorders: System design and experience in canines and denning black bears." Congrats to all the co-authors!
Sara Anderson won a $500 cash award for the poster she submitted to the Medical Alley conference on October 6, 2005. The poster "Comparison of Measurement Methods in Pacing Lead-Tissue Interactions: Effect on Impedance Measurements" competed in the "modeling and simulation" category. Congratulations Sara!
Paul Iaizzo was recently awarded a Nash Avery grant in the amount of $15,000 for the proposal "Opioid preconditioning in normal and dystrophic heart muscle." The goal of this research is to better define the potential benefits of specific opioid-based anesthesia so it may be best appleid to patients with Duchenne Muscular Dystrophy.
"Novel visualization of lead extraction using various approaches performed on three chronically implanted isolated canine hearts," an abstract poster, will be presented at the AHA 2005 Annual Meeting (Dallas, November 13-16, 2005). Co-authors are Charles Love (Ohio State University), Sarah Ahlberg, Prasanga Hiniduma-Lukuge, and Paul Iaizzo.
The abstract "Early Regional Electrical Activation of the LV Myocardium is Associated with Prolonged Electrical-Mechanical Delay in vivo" was accepted as an oral presentation at the AHA 2005 Annual Meeting (Dallas, November 13-16, 2005). Co-authors include: Trent Fischer, Nicholas Skadsberg (PhD, 2004), Daniel Kaiser, Jodi Koehler, and Paul Iaizzo. Congratulations and good luck!
"A novel ex vivo heart model for the assessment of cardiac pacing systems" was recently accepted by the Journal of Biomechanical Engineering for publication in the November 2005 issue. Co-authors include: Tim Laske (PhD, 2004), Nick Skadsberg (PhD, 2004), and Paul Iaizzo.
The manuscript "High pacing impedances: Are you overtorquing your leads?" has been accepted for publication in Pacing and Clinical Electrophysiology (September 2005 issue). Congrats to co-authors Tim Laske (PhD, 2004), Sarah (Vincent) Vieau (MS, 2004), Nick Skadsberg (PhD, 2004), and Paul Iaizzo!
Charles Soule earned his masters degree (CBS) on June 20, 2005 after successfully defending his thesis "Comparison of the protective effects of glucose metabolism and opioid preconditioning against hypoxic damage in swine skeletal muscle." WAY TO GO, CHARLES!! Congrats!
Congratulations to Matt Adams who successfully defended his masters thesis in Biomedical Engineering on June 16, 2005. His thesis was titled "Complications and design recommendations associated with chronic implant of intrathecal catheters." Great job, Matt!!
Sarah Handahl successfully defended her master's thesis on May 19, 2005. Her Plan B project was titled "Effect of pacing site on systolic and diastolic mechanical restitution curves." Congratulations, Sarah!
"The potential benefits of 1.5% hetastarch as a cardioplegia additive" has been published in Biochemical Pharmacology (69: 1553-1558, 2005). Congratulations to co-authors James Coles Jr (PhD, 2002), Daniel Sigg (PhD, 2001) and Paul Iaizzo!
Congratulations to Neda Shahghasemi (undergraduate, Directed Research) who won FIRST PLACE in the poster competition (devices category) at the Design of Medical Devices annual conference (April 13-15, 2005)! Neda's colorful poster, entitled "Muscle force assessment device," reported on the research, design and manufacture of a device that measures the amount of force generated by the tibialis anterior muscle of mice (in conjunction with Sarah Frommer's study related to Duchenne Muscular Dystrophy). Great job, Neda!
Congratulations to Charles Soule, Jinback Hong, Daniel Sigg, James Coles, Peter Oeltgen, Hank Harlow and Paul Iaizzo! Their manuscript "Hibernation induction trigger reduces hypoxic damage of swine skeletal muscle" was accepted for publication in Muscle & Nerve.
The Visible Heart lab was represented at the 2005 Heart Fair at the Science Museum on Saturday, March 5th. Staff and students displayed human hearts, along with various pacemakers and a defibrillator. They also fielded questions about the Visible Heart CD which was available for participants to explore at the event. Pictured left to right: Jackie Youtsos, Sara Street, Sarah Handahl, Monica Mahre, Mike Kimmel, and Neda Shahghasemi.
Jackie Youtsos, an undergraduate conducting directed research in our lab, was recently accepted to present her research at the 19th Annual National Conference on Undergraduate Research meeting, held in Lexington, VA on April 21-23, 2005. Congratulations Jackie!
An article about the Visible Heart Laboratory, titled Device and Conquer, appeared in the Winter 2004 issue of Pictures of Health, published by the Academic Health Center at the University of Minnesota.
The Handbook of Cardiac Anatomy, Physiology and Devices, edited by Paul Iaizzo, will be released in early 2005 by Humana Press. This 33-chapter book features chapters on anatomy of the heart, cardiac physiology and assessment, and devices and therapies for treating heart disease. Thanks to Paul for all his hard work and faith in bringing this ambitious project to reality!!
Mike Kimmel and Sarah Handahl are currently interning at the CRM division at Medtronic, Inc. in addition to their RA responsibilities here at the U of MN (Spring 2005).
Congratulations to Mike Kimmel who passed his preliminary orals in BME on December 15, 2004. The title of Mike's Oral Prelim Presentation was "Swine models for optimization of biventricular pacing therapies as treatments for heart failure."
Congratulations to Tony Dupre who earned his MS degree in Biomedical Engineering with his thesis titled "The development of an in vitro swine heart model for the evaluation of an epicardial radiofrequency ablation device" on December 8, 2004. Tony has recently accepted a job at Boston-Scientific SciMed.
Congratulations to Nick Skadsberg who provided an excellent public defense of his PhD project in December 2004. The title of Nick's PhD Thesis is "Single site cardiac pacing: Influence of pacing site on electrophysiology and performance in the normal swine heart."
(November 17, 2004) At the recent Biomedical Engineering Institute Medical Alley poster sessions, Nick Skadsberg was the recipient of the LHI Award and Mike Kimmel was the recipient of the Medtronic Award. Congratulations!
Paul Iaizzo and Nick Skadsberg traveled to New Orleans for the AHA Annual Scientific Sessions (November 7-10, 2004). Two abstracts were accepted for presentation:
Iaizzo PA, Laske TG, Skadsberg ND, Vincent SA, Padeletti L. Right ventricular septal lead placement-Are you really on the anterior wall?
Skadsberg ND, Coles Jr. JA, Iaizzo PA. Ventricular outflow tract pacing preserves left ventricular activation pattern thereby optimizing hemodynamic function.
On October 19, 2004 we hosted Earl Bakken for a tour of our labs.
During his 2-hour visit, Mr. Bakken observed a Visible Heart experiment
and asked many relevant questions about our research, before graciously
posing for pictures with our lab staff, graduate students and Medtronic
collaborators. Mr. Bakken's visit was planned in conjunction with
the Lillehei Heart Institute's 50th Anniversary of Open-Heart Surgery
using Cross-Circulation event (October 19-20, 2004), a special celebration
attracting numerous U of MN research pioneers/clinicians (i.e.,
DeBakey, Varco, Lillehei family) as well as families of patients
who benefited from their innovative techniques.
Our laboratory had a poster and an oral presentation accepted for the 2004 XI International Symposium on Progress in Clinical Pacing conference in Rome, Italy, November 30-December 3. The two abstracts accepted were:
Skadsberg ND, Kaiser DR, Fischer TM, Iaizzo PA. Single site pacing induced electrical dyssynchrony and the hemodynamic results. XI International Symposium on Progress in Clinical Pacing, Rome, Italy, 2004. (Oral Presentation)
Kimmel MK, Skadsberg ND, Kaiser DR, Fischer TM, Iaizzo, PA. Effects of latest depolarization biventricular pacing on the acutely infarcted swine heart. XI International Symposium on Progress in Clinical Pacing, Rome, Italy, 2004. (Poster)
We presented a poster at the 8th Annual Scientific Meeting of the Heart Failure Society of America:
Kimmel MW, Skadsberg ND, Byrd CL, Wright JD, Laske TG, Iaizzo PA. Comparison of latest depolarization biventricular pacing with single-site pacing in healthy swine hearts. Heart Failure Society of America, 8th Annual Scientific Meeting, Category: Electrophysiology, Arrhythmias, Sept. 13, 2004, Toronto, Canada. Supplement to J of Cardiac Failure. Vol. 10(4): Pg. S71, August 2004. (Poster)
(July 26, 2004) Margaret Nelson, Erika Sandell, and Sonja Lukas did an excellent job presenting their Doctorate in Physical Therapy research project titled "Quantitative analyses of dorsiflexor forces in marathon runners: A pilot study."
Paul Iaizzo, Tim Laske and Woohyek
Choi recently received approval for their
patent application on a "system and method for determining tissue contact of
an implantable medical device within a body" (US Patent 6,714,806). This patent is licensed to the University of Minnesota and Medtronic, and is jointly held by Medtronic, Inc. and Paul Iaizzo.
Paul Iaizzo and Tim Laske also
received patent approval for a "system and
method for determining location and tissue contact of an implantable medical
device within a body" (US Patent 6,671,550). This patent is licensed to the University of Minnesota and Medtronic, and again is jointly held by Medtronic, Inc. and Paul Iaizzo.
(June 15, 2004) Sarah Vincent successfully completed her MS degree in Biomedical Engineering. The title of her project was "The use of opioids as a means to induce preconditioning in diseased human left ventricular trabeculae." Great job, Sarah!
Two abstracts have been accepted for presentation at the 14th World
in Cardiac Electrophysiology and Cardiac Techniques Cardiostim 2004
conference in Nice, France (June 16-19, 2004):
Nicholas D. Skadsberg, MS, James A. Coles, Jr., PhD, Timothy G. Laske, MS, Paul A. Iaizzo, PhD. "Optimal right ventricular pacing: an anatomical perspective." (University of Minnesota and Medtronic, Inc.)
Sanjeev Saksena, MD, Hygriv B. Rao, Nicholas Skadsberg, Paul Iaizzo, PhD and Sina Zaim, MD. "Do underlying disease states affect the mechanisms of atrial fibrillation in humans?" (University of Minnesota, RWJ Medical School, UMD NJ Medical School, and Passaic General Hospital, Warren, NJ)
(May 11, 2004) Kevin Fitzgerald successfully completed his MS degree in Biomedical Engineering, he gave an excellent presentation on his project entitled "The use of an implantable epidural spinal cord stimulation device as a means to induce opioid preconditioning of the swine heart." Super job, Kevin!
Tim Laske (PhD in Biomedical Engineering, 2000-2004), Paul Iaizzo, and Nick Skadsberg (current PhD candidate in Biomedical Engineering) will travel to San Francisco in May 2004 to present an abstract at the 25th Annual NASPE Scientific Sessions. The abstract, "Analysis of atrial pacing impedance variations using an isolated heart model," highlights a study to recreate clinical situations that result in unusually high pacing impedances in order to provide insight into the clinical consequences of these situations. Co-authors also include Alex Hill (PhD in Biomedical Engineering, 1999-2003) and Sarah Vincent (current MS candidate in Biomedical Engineering).
Paul Iaizzo is the Program Chair of The President's Commissioned Inderdisciplinary Conference on Medical Devices/Design of Medical Devices Conference that will be held at the McNamara Alumni Center (April 7, 2004) and Radisson Hotel Metrodome (April 8-9, 2004). This conference brings device designers, entrepreneurs and researchers together to share perspectives on medical device design and successful production of new devices to solve health care needs.
Paul Iaizzo just received $10,000 from the Nash Avery Search for Hope Research Fund (Paul & Sheila Wellstone Muscular Dystrophy Center) to fund research to target preconditioning drugs (delta-opioid agonists) and evaluate their level of protection in both normal and dystrophic heart muscle (left ventricular trabeculae) and skeletal muscle. In addition, the maximum force production and onset of fatigue in the dorsiflexor muscles will be evaluated in both normal and dystrophic dogs. Both Sarah Vincent (current MS candidate in Biomedical Engineering) and Sarah Frommer (graduate student) will be working on this project in the upcoming months.
In March 2004, Paul Iaizzo and Tim Laske (PhD in Biomedical Engineering, 2000-2004) completed a number of bear studies in Grand Rapids and Ripley, in collaboration with the Department of Natural Resources.
Sarah Vincent, Tony Dupre, Kevin Fitzgerald (all current MS candidates in Biomedical Engineering) and Mike Kimmel (current PhD candidate in BiomedicalEngineering) represented our lab at the Lillehei Heart Institute Heart Fair at the Minnesota Science Museum on March 6, 2004.
Tim Laske (PhD in Biomedical Engineering, 2000-2004) successfully defended his doctoral thesis in February 2004. The title of his thesis was "The application of an isolated perfused working heart model to the design of endocardial pacing systems." Tim's thesis focused on the use of an isolated perfused large mammalian heart preparation as a tool for studying several aspects of cardiac stimulation and sensing. Tim is currently the Senior Director of Cardiac Rhythm Management-Therapy Delivery at Medtronic, Inc. (MN).
As the leader of the Cardiovascular Physiology Interest Group that is funded by the Biomedical Engineering Institute, Paul Iaizzo has organized various lab tours and presentations in the last several months. Group members were introduced to research in our labs in October 2003. Subsequent meetings have featured Dick Bianco's labs (February 2004) and a presentation by Dr. H. Fred Downey from the University of Texas, Fort Worth (also in February 2004). The upcoming April meeting will hopefully highlight Dr. Zhang's laboratory at the University of Minnesota.
Alex Hill (PhD in Biomedical Engineering, 1999-2003) submitted the manuscript, "In vitro studies of human hearts," to The Annals of Thoracic Surgery in February 2004. The objective of this research was to describe a unique isolated heart preparation, utilizing human hearts not viable for transplant, which allows for physiological perfusion and endocardial imaging. Staff members as well as current and past graduate students are co-authors including: Tim Laske, James Coles Jr., Daniel Sigg, Nick Skadsberg, Sarah Vincent, Charles Soule, Bill Gallagher and Paul Iaizzo.
Paul Iaizzo served as a co-course director of the Advanced Cardiac Physiology and Anatomy course again in January 2004. Attending the course were approximately 80 people representing 3M, Data Sciences International, Guidant, MedAmicus, Medtronic, St. Jude and the University of Minnesota. The course was very well received by students. In addition to Paul, lecturers included current and past graduate students: George Bojanov, James Coles Jr., Kevin Fitzgerald, Alex Hill, Tim Laske, Michael Loushin, Daniel Sigg, and Nick Skadsberg.
Paul Iaizzo edited a 33-chapter book entitled "Handbook of Cardiac Anatomy, Physiology and Devices for the Biomedical Engineer" that was submitted to Humana Press in December 2003. Several current and past graduate students contributed chapters to the book including: Ed Chinchoy, James Coles Jr., Tony Dupre, Kevin Fitzgerald, Alex Hill, Ryan Lahm, Tim Laske, Anna Lindlief, Michael Loushin, Daniel Sigg, Nick Skadsberg and Sarah Vincent. We expect the book will be ready for release in October 2004.
Alex Hill (PhD in Biomedical Engineering, 1999-2003) earned his doctoral degree in December 2003. Alex's thesis, entitled "Large mammalian comparative cardiac anatomy," summarized his research on the use of animal models in understanding cardiovascular physiology and designing new therapeutics for cardiovascular disease. Alex is currently a Senior Scientist at Medtronic, Inc. (MN).
Current UROP students for Spring 2004 semester are: David Choi (Project title: "Characteristics of cardiac electrical conduction patterns associated with alternate site pacing of the heart") and Laura Skadsberg (Project title: "Hemodynamic assessment of alternate site pacing study").
Nick Skadsberg (current PhD candidate in Biomedical Engineering) passed his oral exams in September 2003. Nick's continuing research centers around alternative site pacing methodologies both in situ and in vitro on the Visible Heart® apparatus. His research investigates the electrophysiological, hemodynamic and mechanical effects that result from pacing various atrial and ventricular anatomical locations. This research employs a high-resolution, non-contact mapping system (ESI, Inc., St. Paul, MN) that reconstructs the three-dimensionality of the chamber of interest and accurately records the heart's electrical depolarization activity.
Jerome Socha (MS in Biomedical Engineering, 2003) earned his masters degree in March 2003. In his thesis, Jerome described a prototype mobile unit that can be used for future patient studies on preventing pressure ulcers using focal cooling. Jerome is employed by Lockheed Martin, and currently works and resides in Texas.
Lina Alzate (MD, MS in Biomedical Engineering, 2001-2003) successfully defended her masters Plan B thesis in 2003. Project title: "Focal warming during induction of hypothermia by surface cooling: Feet warming experiments and analysis of mean skin temperature and shivering response. Lina is currently employed by Medtronic, Inc. (MN).