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Surface or transmural electromyography in our lab entails the recording, detection, and analysis of cardiac activity recorded from the epicardial surface or within the heart wall. Recording can be accomplished with the use of needle electrodes (needle electromyography or EMG) or multielectrode arrays for the acquisition of the monophasic action potential (MAP). MAP recordings are important for reconstructing the time course of repolarization of myocardial cells . For clinicians, MAPs are important tools for diagnosing arrhythmias or providing valuable information about local myocardial electrophysiology. It is also considered that new applications for monitoring regional differences in MAP morphologies may be to define areas in which to administer gene or cell therapies.
Studies that involve MAP recording can often amass a large volume of data with thousands of epochs from multiple sites. Subsequently, manual analysis of obtained data sets can be time consuming and labor intensive. Furthermore, manual evaluation can be susceptible to inter-observer variability that may significantly influence the interpretation of the analyses.
Some of the research in our lab involves designing specialized hardware and software that can ease this burden. Specifically, we have developed algorithms and user interfaces for the annotation of MAP signals at key fiducial points without the reliance on intense signal filtering or special hardware . Our algorithms are subsequently tested within animal and human hearts that are functioning under venous conditions such as normal sinus rhythm and induced focal cardiac ischemia.
Our investigative approach incorporates several verification steps to minimize the need for labor intensive annotation corrections. Our current application also has a convenient graphical user interface (GUI) with many features that make viewing, saving, and annotation of recorded MAP signals efficient; it also incorporates features for manual correction. We believe that this research has clinical significance for required MAP analyses elicited by pathological conditions as well as for studying the effects of pharmacologic drugs.
Dual channel action potential viewer. The top graph shows a
normal sinus rhythm signal from an electrode
placed in the non-ischemic region of the heart. The bottom graph shows the ischemic signal from the
same heart with an electrode placed distal to a vascular clamp on the third branch of the left anterior
descending artery. Both channels are acquired simultaneously. The bottom of the panel displays the control buttons
and screen outputs for each channel. Screenshot by Maneesh Shrivastav. Copyright Visible Heart Lab/Medtronic.
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