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• Paul A. Iaizzo, Ph.D.
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Home > Research

Areas of research conducted in the Visible Heart® Laboratory

Cardiac

• Cardiac physiology (functional assessment)
• Large mammalian comparative cardiac anatomy
• Cardiac devices, testing, and design
• Visible Heart: Functional cardiac anatomy using a 4-chamber isolated heart preparation of various large mammalians including human hearts
• Electrophysiology, surface and noncontact mapping
• Pharmacological approaches to cardioprotection
• Chronic ischemia and/or heart failure models
• Opioid preconditioning in human left ventricular trabeculae
• Heart failure models: dilated cardiomyopathy

Skeletal Muscle

• Anesthetic complications in muscular disorders
• Stimulated muscle force measurements in nueromuscular diseases
• Prevention of hypoxic damage using opioid agonists
• Doxorubicin chemomyectomy

Thermoregulation

• The mechanism of shiver
• Thermal management of the surgical patient
• Cerebral protection using mild hypothermia
• The pathomechanism of Malignant Hyperthermia
• The treatment and prevention of Malignant Hyperthermia
• Wound formation, treatment, and healing

Electrophysiology

• Intracelluar recording and patch clamp techniques
• Surface or transmural electromyography
• Action potential mapping

Spinal Biomechanics

• LTX3000TM Lumbar Rehabilitation System
• Cervical spinal unloading
• Functional rotations and movements of the spine

Hibernating Black Bears

• Stimulated muscle force assessment during hibernation
• The effects and potential use of hibernation induction triggers
• Cardiac function during hibernation: EKG and echocardiographic analyses
• Wound healing during hibernation