Paul A. Iaizzo, Ph.D.

Personal Teaching and Mentoring Philosophy

I consider learning to be a highly individualized process for which my role as a teacher is to assist individuals to identify the modes of learning which work best for them. In fact, my advice to teaching assistants with whom I have worked is to be as creative in their teaching style as possible. By striving to find new creative angles to present information, a natural result is enhanced learning and perceived excitement for the topic. I personally have enjoyed the advances in computer technology that have allowed for dynamic Powerpoint presentations into which I can easily incorporate video clips.

It has been my good fortune to witness nearly 70 graduate students complete their degrees while working in my laboratory. Currently, there are 7 doctoral students and 3 masters students working on their research projects in my lab. Yes, it does take much time and effort to train such a group of students, but the mentoring adventure is what, in part, motivates me to continue searching for funding for my research. Additionally, I have been fortunate to have high degrees of camaraderie amongst the students in my lab, hence they play a large role in training each other. More importantly, the way I look at it, I have come to make many good friends while students have worked with me on my research interests.

Education

Academic Positions

Publications

List of publications available here.

Awards

Sea Grant Pre-doctoral Traineeship (1979-1981)
National Institutes of Health Research Fellowship (1986)
Alexander von Humboldt-Stiftung Research Fellowship (1987-1988)
Alexander von Humboldt-Stiftung Collaborative Research Awards (7 trips to Germany, 1988-1992)
Organization for Economic Cooperation and Development; Research Project on Biological Resource Management, Paris, France (3 week fellowship, 1992)
John Tate Award for Excellence in Academic Advising, University of Minnesota (1995)
Finalist for Horace T. Morse Minnesota Alumni Association Award for Outstanding Contributions to Undergraduate Education, University of Minnesota (1999-2001)
Recipient of the Award for Outstanding Contributions to Postbaccalaureate, Graduate, and Professional Education, University of Minnesota (2002)
Academy of Distinguished Teachers, University of Minnesota (2002)
Academy of Medical Educators, University of Minnesota (2002)
Medtronic Professorship in Visible Heart® Research, University of Minnesota (2004)
Recognition of 5 years of service to the University for organizing the President’s 21st Century Conferences on the Design of Medical Devices (2007)
American Institute for Medical and Biological Engineering (AIMBE), member of College of Fellows (2012)
Institute for Engineering in Medicine Academy of Medical Device Innovators (2013)
Institute for Engineering in Medicine Director’s Award (2013)

Professional Memberships

Professional Activities

University Activities: Academic Health Center

University Activities: Biomedical Engineering

University Activities: Lillehei Heart Institute

University Activities: Other

Departmental Activities: Surgery

Departmental Activities: Integrative Biology and Physiology

Departmental Activities: Anesthesiology

Research Interests

• The physiology of skeletal and cardiac muscle (studied in vivo, in situ and in vitro).
• The pathophysiology of human skeletal muscle (disorders include: malignant hyperthermia, myotonic dystrophy, recessive generalized myotonia, myotonia congenita, Schwartz-Jampel syndrome, paramyotonia, hyperkalemic periodic paralysis, and hypokalemic periodic paralysis).
• The effects of anesthetic agents on the function of extrafusal and intrafusal skeletal muscle and cardiac muscle.
• The development of novel instrumentation and biomedical devices for physiological monitoring, clinical evaluation and/or therapeutic use.
• The role of elevated intracellular [Ca2+] in: 1) cell signaling; 2) dystrophic processes within skeletal muscle; and 3) cell toxicity.
• Physiological and pathological oscillations of the musculoskeletal system (e.g., tremor, shiver and clonus).
• Anesthetic effects on the physiology of thermoregulation and biomedical applications of heat transfer in humans.
• Noninvasive and invasive correlates of wound formation, status, healing and prevention: development of animal models, effects of anesthetics and design of biomedical instrumentation.
• Cervical and lumbar spinal cord biomechanics and management of back pain

Outside Interests and Activities

• Running, tennis, volleyball, basketball, hockey, rollerblading, hiking and biking
• Fishing and fly-fishing
• Coaching soccer: recreational and club teams, both outdoor and indoor; E -level coaching license
• Coaching basketball: recreational (4th-8th grades), school, AAU, and travel club teams

1997 Girls  7A		State Champions
1998 Girls  8A		State Champions
1998 Girls  6AA		State Runner-ups
1999 Girls  7AAA		State Champions
2000 Girls  8AAA		State Champions
2004 Girls  8AAA		State Runner-ups

• Gardening, home repairs and woodworking

Previous Teaching Experiences

Invited Lectures

1. "Relaxation of skeletal muscle: do parvalbumins play a role?," Neurologische Klinik der Technischen Universität München, Munich, FRG, August 27, 1986.
2. "Power-spectral analysis of physiological and pathological oscillations of the ankle," Neurologische Klinik der Technischen Universität München, Munich, FRG, August 28, 1986.
3. "The role of parvalbumins in the relaxation of frog skeletal muscle," Abteilung für Allgemeine Physiologie der Universität Ulm, Ulm, FRG, July 22, 1987.
4. "The diagnosis of malignant hyperthermia," Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA, December 22, 1987.
5. "The effects of halothane on malignant hyperthermia susceptible skeletal muscle," Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA, December 23, 1987.
6. "Physiology of muscular contraction," Department D'Anesthesie-Reanimation Chirurgicale I, Centre Hospitalier Regional DeLille, Lille, France, May 16, 1988.
7. "The effects of halothane and isoflurane on Ca2+ mobilization in rat hepatocytes," Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA, May 31st, 1989.
8. "New insights into the pathophysiology of malignant hyperthermia," Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA, June 7th, 1989.
9. "The effects of anesthetic agents on intracellular Ca++," Neurologische Klinik der Technischen Universität München, Munich, FRG, December 7th, 1989.
10. "Mechanical and electrical properties of resealed fiber segments of human skeletal muscle," Departments of Anesthesiology and Physiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC, USA, March 1st, 1990.
11. "The use of resealed fiber segments of human skeletal muscle to study mechanical and electrical properties," Department of Physiology, Indiana University, Terre Haute Center for Medical Education, Terre Haute, IN, USA, April 23, 1990.
12. "Resealed fiber segments for the study of electrical and mechanical properties of human skeletal muscle," Department of Pharmacology, University of North Dakota, Grand Forks, ND, USA, May 3rd, 1990.
13. "The use of resealed fiber segments for the study of the pathophysiology of human skeletal muscle," Department of Anesthesiology, University of Minnesota, Minneapolis, MN, USA, July 31, 1990.
14. "Electrophysiology of muscle disorders," Department of Veterinary Biology, University of Minnesota, Minneapolis, MN, USA, January 17, 1991.
15. "In vitro electrophysiological studies of myotonic muscle," Department of Neurology, University of Minnesota, Minneapolis, MN, USA, February 14, 1991.
16. "In vitro contracture testing to determine susceptibility to malignant hyperthermia," Department of Anesthesiology, University of Minnesota, Minneapolis, MN, USA, May 26, 1991.
17. "Forced air cooling following exercise-induced heat stress," Department of Anesthesiology Research Conference, University of Minnesota, Mpls., MN, June 11, 1991
18. "Tremor, shiver and clonus," Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, September 10, 1991
19. "In vitro contracture test," Department of Anesthesiology, University of Minnesota, Minneapolis, MN, USA, 1st Annual Clinical Symposia, November 9, 1991.
20. "Investigations into the pathophysiology of human skeletal muscle," Department of Physiology, University of Minnesota, Minneapolis, MN, USA, February 14, 1992.
21. "Anesthetics and intracellular Ca2+", Department of Anesthesiology Research Conference: University of Minnesota, Mpls, MN, April 14, 1992
22. "The physiology of thermoregulation and the clinical occurrence of hypothermia," Department of Kinesiology, University of Minnesota, Minneapolis, MN, USA, May 18, 1992.
23. "Physiological implications of malignant hyperthermia in humans and in the pig model," Lehrstuhl für Tierzucht der Technishen Universität München, Freising-Weihenstephen, Germany, July 30, 1992.
24. "Malignant hyperthermia and temperature regulation," Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere Fachbereich Physiologische Grundlagen der Tierhaltung, Dummerstorf-Rostock, Germany August 3, 1992.
25. "Intraoperative patient warming by convection: hygiene aspects with forced air," Zentrum Anaesthesiologie, Universität Göttingen, Göttingen, Germany, August 5, 1992.
26. "The physiology of thermoregulation: the consequences of hypothermia," Abteilung für Allgemeine Physiologie der Universität Ulm, Ulm, Germany, August 6, 1992.
27. "Thermoregulation in humans," Institut für Anaesthesiologie, Universität Erlangen, Erlangen, Germany October 7, 1992.
28. "The physiology of thermoregulation", Department of Anesthesiology Research Conference: University of Minnesota, Mpls, MN, January 7, 1993
29. "Increased muscle excitability: myotonia," Department of Neurology, University of Minnesota, Minneapolis, MN, USA, April 3, 1993.
30. "Electrophysiological studies of human skeletal muscle," Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA, April 20, 1993.
31. "The measurement of ankle torque for the diagnosis of periodic paralysis", Department of Anesthesiology, University of Minnesota, Mpls, MN November 30, 1993
32. "Thermal balance during an episode of malignant hyperthermia," Abteilung für Anästhesiologie und Intensivmedizin, Rehabilitaionskrankenhaus Ulm, Ulm, Germany, September 21, 1993.
33. "Thermal balance during an episode of malignant hyperthermia,"Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, January 3, 1994
34. "Thermoregulation and malignant hyperthermia," Institut für Tierzucht und Hausteirgenetik, Justus-Liebig-Universität, Gießen, Germany, May 5, 1994.
35. "Malignant hyperthermia: an update,"Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, September 6, 1994
36. "Porcine model to study wound formation, healing and prevention," 3M Health Care Division, St. Paul, MN, USA, October 11, 1994.
37. "Temperature modulated pressure ulcers: a porcine model," Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA, October 25, 1994.
38. "Porcine model to study wound formation, healing and prevention," Research Animal Resources, University of Minnesota, Minneapolis, MN, USA, November 15, 1994.
39. "Malignant hyperthermia: variability in clinical presentation," Department of Anesthesiology, Mayo Clinic, Rochester, MN, USA, January 25, 1995.
40. "Myotonic disorders," Department of Neurology, University of Minnesota, Minneapolis, MN, USA, February 8, 1995.
41. "Biomedical aspects of heat transfer in humans," Engineering, Fachhochschule Anhalt, Köthen, Germany, March 27, 1995.
42. "Malignant hyperthermia: clinical presentation," Department of Neurology, Medizinishen Fakultät der Martin-Luther-Universität, Halle, Germany, March 28, 1995.
43. "The use of fluorophlores to monitor modulations in intracellular [Ca2+] in skeletal muscle," Musckelbiologie and Wachstum, Forschungsinstitut für die Biologie landwirtschaftlicher Nutztiere Fachbereich, Dummerstorf-Rostock, Germany, March 29, 1995.
44. "Malignant hyperthermia: variability in clinical presentation", Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, May 2, 1995
45. "Muscle force assessment in neuromuscular diseases," Muskelzentrum der Universität Ulm, Ulm, Germany, May 15, 1995.
46. "Malignant hyperthermia: muscle properties," Versuchsstation Thalhausen-Lehrstuhl für Tierzucht, Technische Universität München, Munich, Germany, May 23, 1995.
47. "Prevention of pressure ulcers by focal cooling," Center for Wound Healing and Reparative Medicine, Department of Surgery, University of Minnesota, Minneapolis, MN, USA, February 5, 1996.
48. "Prevention of pressure ulcers by focal cooling", Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, March 12, 1996
49. "Prevention of pressure ulcers by focal cooling," Augustine Medical, Inc., Eden Prairie, MN, April 3, 1996.
50. "Muscle force assessment in neuromuscular disorders," Department of Neurology, Medizinishen Fakultät der Martin-Luther-Universität, Halle, Germany, May 2, 1996.
51. "Prevention of pressure ulcers by focal cooling," Muskelzentrum der Universität Ulm, Ulm, Germany, May 6, 1996.
52. "Anesthetic complication in muscle disorders", Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, August 6, 1996
53. "Anesthesia and Neuromuscular Disorders," Departement Anästhesie der Universität Kantonsspital Basel, Basel Switzerland, September 30, 1996.
54. "Human thermoregulation," Departement Anästhesie der Universität Kantonsspital Basel, Basel Switzerland, October 1, 1996.
55. "Anesthetic complications and neuromuscular disorders," Department of Anesthesiology, United Hospital, St. Paul, Minnesota, December 5, 1996.
56. "Calcium dysregulation during anesthetic complications and neuromuscular disorders," Department of Laboratory Medicine, Jena, Germany, January 30, 1997.
57. "Anesthetic complications and neuromuscular disorders," Department of Neurology, Medizinishen Fakultät der Martin-Luther-Universität, Halle, Germany, January 30, 1997.
58. "Why perform clinical research?",  Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, March 15, 1997
59. "Assessment of stimulated muscle force in humans," Clinical Neurosciences Conference,  Department of Neurology, University of Minnesota, September 2, 1997.
60. "Assessment of stimulated muscle force in humans," Department of Animal Physiology, University of Wyoming, Laramie, Wyoming, September 23, 1997.
61. "Axial spinal unloading using an LTX3000TM lumbar rehabilitation system," Muskelzentrum der Universität Ulm, Ulm, Germany, October 9, 1997.
62. "The physiological response to lumbar traction in humans," Department of Neurology, Medizinishen Fakultät der Martin-Luther-Universität, Halle, Germany, October 13, 1997.
63. "Stimulated muscle force assessment in humans," Tage der Elektrotechnik, Biomedizinschen Technik, Fachhochschule Anhalt, Köthen, Germany, October 15, 1997.
64. "Force assessment in overwintering black bears",  Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, January 13, 1998
65. "Thermoregulation in humans and swine: a comparative analysis," Versuchsstation Thalhausen-Lehrstuhl für Tierzucht, Technische Universität München, Munich, Germany, April 17, 1998.
66. "In vivo stimulated force assessment for diagnosis and measurement of clinical outcomes," Muskelzentrum der Universität Ulm, Ulm, Germany, April 21, 1998.
67. "Critical thresholds for pressure ulcer formation in a porcine model: prevention by focal cooling," Biomedizinschen Technik, Fachhochschule Anhalt, Köthen, Germany,  April 24, 1998.
68. "The physiological response to lumbar traction in humans," Departement Anästhesie der Universität Kantonsspital Basel, Basel Switzerland, September 9, 1998.
69. "An in-vitro four chamber working swine heart model," Faculty Research Highlights, Biomedical Engineering, University of Minnesota, Minneapolis, MN, USA, September 29, 1998.
70. "An ex-vivo 4-chamber working heart model", Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, January 1999
71. "Studies in an animal model of the human working heart," Department of Neurology, Medizinishen Fakultät der Martin-Luther-Universität, Halle, Germany, April 14, 1999.
72. "An ex vivo working heart model: a collaborative project between the University of Minnesota and Medtronic," Biomedizinschen Technik, Fachhochschule Anhalt, Köthen, Germany, April 15, 1999.
73. "Collaborative research, academic and industry partnerships," BioRegioUlm and the Muskelzentrum der Universität Ulm, Ulm, Germany, April 16, 1999.
74. "An ex vivo working heart model: video images for education," LifeSource, Minneapolis, MN, May 6, 1999.
75. "Why clinical research?," Annual Clinicians Meeting, Spinal Designs International, Hinkley, MN, May 19, 1999.
76. "An ex-vivo 4-chamber working heart model," Department of Cardiology, Universität Ulm, Ulm, Germany, July 30, 1999.
77. "Assessment of stimulated muscle force in humans and hibernating black bears," Medtronic Scientific Forum Presentation, Medtronic, Fridley, MN, August 4, 1999.
78. An ex-vivo 4-chamber working heart model," Department of Anesthesiology, Mayo Clinic, Rochester, MN, September 15, 1999.
79. Gearing up for the next 50 years, Keynote speaker, Catheter Related Technology Symposium, Medtronic, Fridley, MN, September 21, 1999.
80. "Clinical research," International Academy of Orthopedic Medicine, St. Paul, MN, November 11, 1999.
81. "Pain and pain mechanisms," International Academy of Orthopedic Medicine, St. Paul, MN, November 11, 1999.
82. "An ex-vivo 4-chamber working heart model," LifeSource, St. Paul, MN, January 11, 2000.
83. "Why and what research to perform?," Department of Anesthesiology Research Conference, University of Minnesota, Mpls, MN, October 3, 2000
84. "Stimulated muscle force assessment: the ICU to hibernating bears," Department of Neurology, Universität Regensburg, Germany, April 19, 2001.
85. "Stimulated muscle force assessment: the ICU to hibernating bears," Department of Veterinary Pathobiology, University of Minnesota, Minneapolis, MN, September 12, 2001.
86. "Force assessment and weakness in the ICU," Clinical Neurosciences Conference, University of Minnesota, Minneapolis, MN, February 12, 2002.
87. "The Visible Heart" Health Informatics Seminar, University of Minnesota, Minneapolis, MN, February 14, 2002.
88. "The cardiac conduction system," Therapy Research, Cardiac Rhythm Management, Guidant Corporation, April 17, 2002.
89. "Muscle contraction," Applied Research, Boston Scientific, Scimed, August 16, 2002.
90. "Skeletal muscle force assessment: from humans to bears," Department of Biomedical Engineering, Marquette University, Milwaukee, WI, October 4, 2002.
91. "The Visible Heart: the collaborative development and use of this educational tool by the University of Minnesota and Medtronic," Biomedical Engineering Society Meeting, Houston, October 24, 2002.
92. "Induction of mild hypothermia for cerebral protection," Design of Medical Devices Conference, University of Minnesota, Minneapolis, MN, April 24, 2003.
93. "The Visible Heart®: a large mammalian isolated heart model," Department of Surgery Transplant Conference, University of Minnesota, May 7, 2003.
94. "Update on human anatomical research," Pediatric EP Focus Group, Medtronic Cardiac Rhythm Management, Fridley, MN, September 15, 2003.
95. "The Visible Heart®: functional cardiac anatomy," Department of Medicine, University of Minnesota, January 14, 2004.
96. "Why study the hibernating black bear?," Department of Biomedical Engineering, University of Minnesota, April 19, 2004.
97. "The Visible Heart® Center," Medtronic Cardiac Rhythm Management, Fridley, MN, September 2, 2004.
98. "The Visible Heart® Center," Medtronic Minnesota Chapter American Society of Mechanical Engineers, University of Minnesota, Minneapolis, MN, September 22, 2004.
99. "A working industry/University of Minnesota Relationship," Nanotherapy Workshop, University of Minnesota, Minneapolis, MN, November 15, 2004.
100. "The Visible Heart™ Center," Minnesota Microscopy Society, St. Paul, MN, February 17, 2004.
101. "The Visible Heart™: video and simulation," Universität Ulm, Ulm, Germany, April 21, 2005.
102. "Maintenance of muscle during hibernation," Universität Ulm, Ulm, Germany, April 22, 2005.
103. "The Visible Heart®: functional cardiac anatomy," Universität Regensburg, Regensburg, Germany, April 26, 2005.
104. "The Visible Heart®: functional cardiac anatomy," Veterans Administration Hospital, San Juan, Puerto Rico, August 10, 2005.
105. "The Visible Heart® Center: Technical Forum, Medtronic Production and Engineering," Villalba, Puerto Rico, August 11, 2005.
106. "The Visible Heart®Center: Technical Forum, Medtronic Production and Engineering," Juncos, Puerto Rico, August 11, 2005.
107. “Translational research: from the bear den to the bedside,” Technical Forum, Cardiac Rhythm Management, Medtronic Headquarters, Minneapolis, MN, August 19, 2005.
108. “Translational research: from the bear den to the bedside,” Minneapolis Surgical Society, Minneapolis, MN, September 19, 2005.
109. “Translational research: from the bear den to the bedside,” Dialogue North, Itasca Community College Foundation, Grand Rapids, MN, April 27, 2006.
110. “A review of cardiac physiology and anatomy,” Transoma Medical, Minneapolis, MN, June 26, 2006.
111. “Translational research: from the bear den to the bedside,” Bioanalytik Weihenstephan, Technische Universitat Munchen, Freising, Germany, August 22, 2006.
112. “Cardiac pacing: the lead-tissue interface,” Department of Applied Physiology, University of Ulm, Ulm, Germany, August 23, 2006.
113. “Functional cardiac anatomy: The Visible Heart®,” Grand Rounds: Laboratory Medicine and Pathology, University of Minnesota, October 11, 2006.
114. “The Visible Heart®: an update,” Lillehei Heart Institute, University of Minnesota, January 23, 2007.
115. “Translational research: from the bear den to the bedside,” Lake Region Manufacturing, Annual Business Meeting, Chaska, MN, January 26, 2007.
116. “The hibernating black bear,” 32nd Annual Minnesota Association of Veterinary Technicians Convention, Minneapolis, MN, February 2, 2007.
117. “Malignant hyperthermia: a current view,” Idaho Society of Anesthesiologists Annual Conference, Sun Valley, Idaho, March 3, 2007.
118. “Translational research: from bear den to bedside,” Idaho Society of Anesthesiologists Annual Conference, Sun Valley, Idaho, March 4, 2007.
119. “A legacy of collaboration between the University of Minnesota and Medtronic: open-heart surgery, biomedical devices and the Visible Heart® Laboratory”, 2nd Annual Patent Recognition Banquet, Cardiac Rhythm and Disease Management, Medtronic Inc., McNamara Alumni Center, U of MN, Minneapolis, MN, June 7, 2007.
120. “Translational research: from bear den to bedside,” Departement Anästhesie der Universität Kantonsspital Basel, Basel Switzerland, June 27, 2007.
121. “Pharmacological preconditioning to prevent ischemic muscle damage,” Department of Applied Physiology, University of Ulm, Ulm, Germany, June 28, 2007.
122. “The Visible Heart®: Functional Human Cardiac Anatomy,” Josephson and Wellens How to Approach Complex Arrhythmias for EP Fellows, Boston, MA, July 20, 2007.
123. "The Visible Heart®: Functional Human Cardiac Anatomy,” Regions Hospital, Grand Rounds, St. Paul, MN, September 26, 2007.
124. “A legacy of collaboration between the University of Minnesota and Medtronic: open-heart surgery, biomedical devices and the Visible Heart® Laboratory,” Cardiovascular, Medtronic Inc., Fridley, MN, October 15, 2007.
125. “Benefits of Anatomical Donations for Medical Education and Research,” The Minnesota Commission of the Procurement and Use of Anatomical Donations in conjunction with LifeScience Alley, St. Paul, MN, February 7, 2008.
126. “The Visible Heart®: Human Cardiac Anatomy,” 28th Annual Spring Seminar, Minnesota Society of Diagnostic Ultrasound, Minneapolis, MN, March 29, 2008.
127. “The Visible Heart®: Cardiac Devices,” 28th Annual Spring Seminar, Minnesota Society of Diagnostic Ultrasound, Minneapolis, MN, March 29, 2008.
128. “Endoscopic Visualization of the Coronary Veins,” CARDIOSIM 2008, 16th World Congress in Cardiac Electrophysiology and Cardiac Techniques, Nice, France, June 2008.
129. “An Update on The Visible Heart® Project and the Atlas of Human Cardiac Anatomy,” Lillehei Heart Institute, University of Minnesota, October 15, 2008.
130. “From Research to Bedside: perspectives from academia and industry,” LifeScience Alley, Minneapolis, MN, October 28, 2008.
131. “An Update on The Visible Heart® Project and the Atlas of  Human Cardiac Anatomy,” Grand Rounds, Department of Surgery, University of Minnesota, January 27, 2009.
132. “Pharmacological preconditioning to prevent ischemic muscle damage,” Paul and Sheila Wellstone Muscular Dystrophy Center, University of Minnesota, January 30, 2009.
133. “Translational research: from bear den to bedside,” Conservation Biology Graduate Program, University of Minnesota, February 16, 2009.
134. “The Visible Heart® Project and the Atlas of  Human Cardiac Anatomy,” 29th Annual Spring Seminar, Minnesota Society of Diagnostic Ultrasound, Minneapolis, MN, March 28, 2009.
135. “Translational research: from bear den to bedside,” 29th Annual Spring Seminar, Minnesota Society of Diagnostic Ultrasound, Minneapolis, MN, March 2, 2009.
136. “The Visible Heart® Laboratory, and the Atlas of Human Cardiac Anatomy,” Department of Medicine, Martin Luther University, Halle/Saale, Germany, April 24th, 2009.
137. “The Visible Heart® Laboratory, and the Atlas of Human Cardiac Anatomy,” LifeSource, St. Paul, MN, June , 2009.
138. “Translational Research: from the bear den to the patient bedside,” Department of Surgery Grand Rounds, University of Minnesota, August 18, 2009.
139. “The Visible Heart® Project and The Atlas of Human Cardiac Anatomy" at the community education conference Heart of the Matter, St. Joe’s Hospital, St. Paul, MN, October 12, 2009
140. “A Review of Cardiovascular Physiology and An Update on the Visible Heart® Project” LifeSource, St. Paul, MN, October 12 and 14, 2009.
141. “Stimulated muscle force assessment: at the bear den or in an ICU,” Department of Neurology Grand Rounds, University of Minnesota, February 11, 2010.
142. “Physiological Engineering within the Visible Heart® Laboratory: Guiding the laboratory forward to enhance future cardiovascular device designs.” Horizon Series, co-sponsored by: Medtronic’s Bakken Society and Technical Fellows. Minneapolis, MN, February 22, 2010
143. “Physiological Engineering within The Visible Heart® Laboratory: Using Swine Heart to Save Human Lives”.  6th Annual Regional Bioscience Conference, Worthington, MN, March 26, 2010.
144. “The University of Minnesota: One of the Pioneering Institutions in the Field of Cardiovascular Surgery”, 30th Annual Spring Seminar, Minnesota Society of Diagnostic Ultrasound, Minneapolis, MN, March 27, 2010.
145. “Physiological Egineering within the Visible Heart Laboratory.” 2nd Annual UMN CV Retreat, St. John’s University, MN, June 24, 2010
146. “The Visible Heart® Project”, Department of Surgery Grand Rounds, University of Minnesota, August 31, 2010.
147. “The Visible Heart® Laboratory”, Cardiovascular Innovation Seminars, Medtronic, Inc., Mounds View, MN, September 1, 2010.
148. “Functional Anatomy of the Human Heart: The Visible Heart® project.” Mayo Clinic Grand Rounds, Jacksonville, Florida, November 8, 2010.
149. “Functional Anatomy of the Human Heart: The Visible Heart® project.” Medtronic Ventor, Natanya, Israel, December 2, 2010.
150. “Translational Research: from the bear den to the patient bedside.” Young Scientist Roundtable, Wayzata High School, Wayzata, MN Feb 2011.
151. “Translational Research: from the bear den to the patient bedside.”  MiniMed School, University of Minnesota, March 21, 2011.
152. “The Visible Heart® Laboratory: our latest results”, Department of Surgery Grand Rounds, University of Minnesota, January 31, 2012.
153. “New Insights in Heart Physiology.” Jubiläumssymposium, Martin-Luther-Universität, Halle-Wittenberg, April 3, 2012.
154. “Cardiovascular Advances by the University of Minnesota: Past Present and Future.” Boston Scientific Inc., Maple Grove, MN, May 16, 2012.
155. “Malignant Hyperthermia: A Current View.” New River Medical Center, Monticello, MN, July 12, 2012.
156. “The Visible Heart® Project: Journey Inside the Heart.” Paris, France, January 19, 2013.
157. “The Visible Heart® Laboratory and the Atlas of Human Cardiac Anatomy.” Northern Ohio Cardiac Imaging Association, University Hospital, Case Medical Center, Cleveland, OH, April 13, 2013.
158. “The Visible Heart® Lab and the Atlas of Human Cardiac Anatomy Physiological Researh “ Physiological Researh Laboratories, Medtronic, Coon Ropids, MN  August 14, 2013.
159. “The Visible Heart® Laboratory and the Atlas of Human Cardiac Anatomy.” Skirball Research Center, Cardiovasculuar Research Foundation, New York, NY August 19, 2013.
160. “The Visible Heart® Lab and Medtronic: A Partnership between Academia and Insustry.” Annual Meeting Halstad Society, Univerity of Minnesota, Mpls, MN September 12, 2013.
161. “Inside the Human Heart.” I Am Hope LifeSource Symposium, Minneapolis, MN, November 7, 2013.
162. Innovations in Cardiovascular Interventions, “The Visible Heart® Laboratory and the Atlas of Human Cardiac Anatomy.” Tel Aviv, Israel, December 1-4, 2013.

Invited Symposium Lectures

1. 20th Scandinavian Congress of Anaesthesiology, “Pathophysiology of malignant hyperthermia,” Copenhagen, Denmark, June 28, 1989.
2. VII International Congress of Neuromuscular Diseases, “Pathophysiology of malignant hyperthermia.” Co-Chairman of session on “Malignant Hyperthermia,” Munich, Germany, September 19, 1990.
3. 1st Annual Symposia on Clinical Anesthesiology, Department of Anesthesiology, University of Minnesota, “Malignant hyperthermia,” Minneapolis, MNNovember 6, 1991.
4. American Association of Critical-Care Nurses, “Hypothermia post-bypass,” Minneapolis, MN, April 28, 1992.
5. Anaesthesia and Pharmacogenetic Diseases: Malignant Hyperthermia, “Physiology and Biochemistry of Muscle Contraction,” Co-chairman of session on “Muscle contraction,” Padova, Italy, May 22, 1993.
6. Department of Anesthesiology, 6th Annual Clinical and Research Symposium, University of Minnesota, “The induction of mild hypothermia aided by facial warming,” Minneapolis, MN, September 27, 1997.
7. Tage der Elektrotechnik, Fachhochschule Anhalt, “Industry sponsored student research” (keynote lecture), Köthen, Germany, October 14, 1997.
8. Department of Anesthesiology, 7th Annual Clinical and Research Symposium, University of Minnesota, “Force assessment in the ICU,” Minneapolis, MN, November 20, 1999.
9. Department of Anesthesiology, 8th Annual Clinical and Research Symposium, University of Minnesota, “The Visible HeartTM,” Minneapolis, MN, November 18, 2000.
10. 21st Myron B. Laver International Postgraduate Course: Impact of Research on Anaesthesia and Intensive Care, University of Basel, “Physiology and pathophysiology of skeletal muscle,” Basel, Switzerland, March 16-17, 2001.
11. 21st Myron B. Laver International Postgraduate Course: Impact of Research on Anaesthesia and Intensive Care, University of Basel, “Industry-funded basic research,” Basel, Switzerland, March 16-17, 2001.
12. 22nd St. Luke Hospital and Regional Trauma Center’s Annual Surgery Seminar, “Malignant Hyperthermia,” Duluth, MN, January 19, 2002.
13. MSA Anesthesia Educational Symposium, “Clinical Thermoregulation,” Bloomington, MN, February 15, 2002.
14. Arrowhead Region Anesthesia Seminar, “Clinical Thermoregulation,” Duluth, MN, August 18, 2002.
15. Medical Alley’s 3rd Annual Health Care Technology Conference and Expo. “What’s New in Heart Research,” Minneapolis, MN, November 17, 2004.
16. Osteoporose-eine wachsende Herausforderung, Anhaltinischer Therapeutentag,“Osteoporose-Grundlagenforshung: Was können wir vom Winterschlaf des Baren lernen?,” Hettstedt, Germany, April 23, 2005
17. The Joint Meeting of 5th International Conference on Bioelectromagnetism & 5th International Symposium on Noninvasive Functional Source Imaging within The Human Brain and Heart. “Non-contact Mapping and Concomitant Hemodynamic Assessment for the Study of Heart Diseases and their Treatment,” Minneapolis, MN, May 15, 2005.
18. National Association of Transplant Coordinators, National Meeting, “The Visible Heart®: Functional Cardiac Anatomy,” Atlanta, GA, August 2, 2005.
19. Simulation in Healthcare at the University of Minnesota: Transforming Education, “The Visible Heart®,” Minneapolis, MN, November 29, 2005.
20. University of Minnesota Institute for Engineering in Medicine Symposium: A New Direction, “Educational Activities of IEM” and “The Visible Heart®: Device Tissue Interactions, Minneapolis, MN, February 15, 2008.
21. Symposium on Periodic Paralyses (PP) and Excitation-Contraction Coupling (ECC), “Muscle Trophic Maintenance in Man and Other Mammals,” Ulm, Germany, June 23, 2008.
22. 2nd Annual Bakken Surgical Device Symposium: “ Novel Views of Valvular Function: Employing Visible Heart technologies, University of Minnesota, Minneapolis, MN, December 9, 2008
23. 3rd Annual Institute for Engineering in Medicine Educational Symposium: “In Vitro Testing and the Visible Heart®,” University of Minnesota, Minneapolis, MN, December 9, 2010.
24. Jubiläumssymposium von Prof. Karl-Ludwig Schober und 50-jähriges Jubliläum der ersten Herz-Operation mit Hilfe der hallechen Herz-Lungen-Maschine. Keynote Lecture: “Functional Anatomy of the Human Heart: Visible Heart® Project,” Universitatklinkum Halle (Saale), Germany, April 3, 2012.
25. 6th Annual Bakken Surgical Device Symposium: Keynote Lecture, “Cardiovascular Advances by the University of Minnesota: Past Present and Future,” University of Minnesota, Minneapolis, MN, May 16, 2012.
26. International Society for Rotary Blood Pumps: Keynote Lecture, “Back to the Future: Laboratory Research on the Isolated Heart to Enhance Cardiovascular Device Design,” Istanbul, Turkey, September 22, 2012.

Scientific Presentations

1. 8th Annual Society for Neuroscience Meeting, St. Louis, MO, November 5-9, 1978 (poster)
2. 4th Congress of the International Society of Electrophysiological Kinesiology, Boston, MA, August 5-10, 1979 (20-minute slide presentation)
3. 9th Annual Society for Neuroscience Meeting, Atlanta, GA, November 2-6, 1979 (poster)
4. 12th Annual Society for Neuroscience Meeting, Minneapolis, MN, October 31-November 5, 1982 (poster)
5. 34th Annual Fall Meeting of the American Physiological Society, Honolulu, HI, August 20-24, 1983 (poster)
6. 13th Annual Society for Neuroscience Meeting, Boston, MA, November 6-11, 1983 (two posters)
7. 36th Annual Fall Meeting of the American Physiological Society, Niagara Falls, NY, October 14-18, 1985 (poster)
8. 30th Annual Meeting of the Biophysical Society, San Francisco, CA, February 9-13, 1986 (poster)
9. VI International Congress on Neuromuscular Diseases, Los Angeles, CA, July 6-11, 1986 (poster)
10. IV International Malignant Hyperthermia Workshop, York, England, September 4-9, 1986 (15-minute slide presentation)
11. 8th Ludwig Boltzmann Symposium, "Malignant Hyperthermia," Vienna, Austria, March 11-12, 1988 (20-minute slide presentation and poster)
12. Joint Meeting of the Deutsche Physiolgische Gesellschaft (65th meeting) with The Physiological Society, Würzburg, FRG, March 16-19, 1988 (poster)
13. IV Myology Cell Workshop on Malignant Hyperthermia, Jena, DDR, April 16-19, 1988 (20-minute slide presentation)
14. 18th Annual Society for Neuroscience Meeting, Toronto, Canada, November 13-17, 1988 (poster)
15. Festveranstaltung der Neurologischen Klinik und Poliklinik der Technischen Universität München, Munich, FGR, March 11, 1989 (5-minute poster presentation)
16. Association of University Anesthetists 36th Annual Meeting, Rochester, MN, May 4-7, 1989 (20-minute slide presentation)
17. 20th Congress of the Scandinavian Society of Anesthesiologists, Copenhagen, DK, June 26-30, 1989 (15-minute slide presentation and two posters)
18. American Society for Pharmacology and Experimental Therapeutics, Salt Lake City, UT, August 13-17, 1989 (two posters)
19. VII International Congress on Neuromuscular Diseases, Munich, FRG, September 16-22, 1990 (Co-chairman of workshop, one 15-minute slide presentation, one 5-minute slide presentation and two posters)
20. V International Workshop on Malignant Hyperthermia, Munich, FRG, September 22-23, 1990 (two 10-minute presentations)
21. American Society of Anesthesiologists Annual Meeting, Las Vegas, Nevada, October 19-23, 1990 (15-minute slide presentation and one poster)
22. Pharmacology of Thermoregulation Eighth International Symposium, Kananaskis Village, Alberta, Canada, August 25-30, 1991 (two 20-minute slide presentations and one poster)
23. American Society of Anesthesiologists Annual Meeting, San Francisco, CA, October 26-30, 1991 (15-minute slide presentation)
24. VI International Workshop on Malignant Hyperthermia, Hershey, PA, September 17-20, 1992 (5-minute poster discussion and one poster)
25. ENMC Workshop on Non-dystrophic Myotonias and Periodic Paralyses, Ulm, Germany, October 5-6, 1992 (30-minute slide presentation)
26. American Society of Anesthesiologists Annual Meeting, New Orleans, LA, October 18-21, 1992 (5-minute poster-disc and two posters)
27. 6th International Conference on Environmental Ergonomics, Montebello, Quebec, Canada, September 25-30, 1994 (20-minute slide presentation and two posters)
28. American Society of Anesthesiologists Annual Meeting, San Francisco, CA, October 15-19, 1994 (one poster)
29. Annual Meeting of the European Malignant Hyperthermia Group, Annecy, France, May 19, 1995 (10-minute presentation)
30. The Symposium on Advanced Wound Care, Atlanta, GA, April 20-24, 1996 (one poster)
31. VIII International Workshop on Malignant Hyperthermia, Minneapolis, MN, September 4-8, 1996 (poster, 5-minute presentation and panel discussion)
32. American Society of Anesthesiologists Annual Meeting, Orlando, FL, October 17-20, 1998 (one poster)
33. American Heart Association: Scientific Conference on Molecular, Integrative, and Clinical Approaches of Myocardial Ischemia, Seattle, WA, August 9-11, 2001 (two posters)
34. American Physiological Society, Experimental Biology Annual Meeting, New Orleans, LA, April 20-22, 2002 (4 posters)
35. Biomedical Engineering Society Meeting, Houston, October 2002 (1 poster and 30 min talk)
36. American Physiological Society, Experimental Biology Annual Meeting, San Diego, CA, April 12-15, 2003 (2 posters)
37. 7th Annual scientific Meeting of the Heart Failure Society of America, Las Vegas, NA, September 21-24, 2003 (1 poster)
38. American Heart Association, Scientific Sessions, New Orleans, LA, November 7-10, 2004 (1 poster)
39. American Heart Association Scientific Sessions, Dallas, TX, November 13-16, 2005 (1 poster, 1 oral presentation)
40. Heart Rhythm Society Scientific Sessions, Boston, MA, May 17-20, 2006 (1 poster, 1 oral presentation)
41. Medtronic National Sales Meeting, Dallas TX, June 10, 2006, The Visible Heart® and Cardiac Anatomy (Demo/lecture)
42. International Society for Magnetic Resonance in Medicine (ISMRM), May 19-25, 2007, RF safety at 9.4T—Porcine in vivo results.
43. International Society of Minimally Invasive Cardiothoracic Surgery (ISMICS), June 11-14, 2008, Comparative Imaging of Devices and Procedures for the Treatment of Heart Diseases (Laske TG, Liddicoat JR, Iaizzo PA). “Winner of Best Mini Presentation 2008.”
44. IEEE Engineering in Medicine and Biology (EMBC), September 1-4, 2010, Non-invasive muscle force assessment apparatus for use in the intensive care unit (Durfee W, Iaizzo P, Burgstahler B, Ponkshe S).
45. Design of Medical Devices Conference, Minneapolis, MN, April 9-11, 2013. Four posters: 1) 3-Dimensional Reconstructions of the Human Coronary Artery System using Contrast Computed Tomography of Perfusion-fixed Specimens, 2) Conus Arteriosus: An Alternate Pacing Site, 3) Irreversible Electroporation of Cardiovascular Cells and Tissues, and 4) 3D Assessments of Patent Foramen Ovale within Human Hearts: Insights Relative to Design Considerations for Medical Devices.

 

Patents

US Patent Office

1. US5800480: Support apparatus with a plurality of thermal zones providing localized cooling. Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC: Issued September 1, 1998.
2. US5837002: Support apparatus with localized cooling of high-contact-pressure body surface areas. Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC, Stapf DE: Issued November 17, 1998.
3. US5860292: Inflatable thermal blanket for convectively cooling a body: Augustine SD, Iaizzo PA: Issued January 19, 1999.
4. US6010528: Support apparatus which cradles a body portion for application of localized cooling to high-contact-pressure body surface areas: Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC; Issued January 4, 2000.
5. US6033432: Support apparatus with a plurality of thermal zones providing localized cooling. Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC: Issued March 7, 2000.
6. US6119474: Inflatable thermal blanket for convectively and evaporatively cooling a body. Augustine SD, Iaizzo PA: Issued September 19, 2000.
7. US6123716: Support apparatus which cradles a body portion for application of localized cooling to high contact-pressure body surface areas. Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC: Issued September 26, 2000.
8. US6210427: Support apparatus with a plurality of thermal zones providing localized cooling. Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC: Issued April 3, 2001.
9. US6224623: Support apparatus which cradles a body portion for application of localized cooling to high contact-pressure body surface areas. Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC: Issued May 1, 2001.
10. U6487871: Apparatus, system and method for convectively and evaporatively cooling a body. Augustine SD, Iaizzo PA: Issued December 3, 2002.
11. US6497720: Support apparatus with a plurality of thermal zones providing localized cooling. Augustine SD, Iaizzo PA, Sparrow EM, Johnson PS, Arnold RC: Issued December 24, 2002.
12. US 6,514,214: Intravascular Temperature Sensor. Kokate JY, DoBrava EM, Berrada MS, Kimmell S, Prstic S, Berrada M, Hoey M, Bar-Cohen A, Iaizzo PA: Issued Feb 4, 2003.
13. US 6,581,400: Apparatus, system and method for convectively and evaporatively cooling a head. Augustine SD, Iaizzo PA: Issued June 24, 2003.
14. US 6,671,550: System and method for determining location and tissue contact of an implantable medical device within a body: Iaizzo PA, Laske TG: Issued December 30, 2003.
15. US 6,714,806: System and method for determining tissue contact of an implantable medical device within a body: Iaizzo PA, Laske TG, Choi W: Issued March 30, 2004.
16. US 7,045,279: Isolated perfused heart preparation and method for use: Laske TG, Iaizzo PA , Hjelle MA, Morissette J, Wahlstrom DA, Issued May 16, 2006.
17. US 7,529,584: Pacing method: Laske TG, Iaizzo PA: Issued May 5, 2009.
18. US 8,019,437: Lead fixation means: Iaizzo PA, Laske TG: Issued September 13, 2011.
19. US 8,332,035: Pacing Method: Iaizzo PA, Laske TG: Issued December 11, 2012.
20. Pending: Method and apparatus for the induction of hypothermia in which the shivering response is suppressed by focal-facial warming: Iaizzo PA, Augustine SA: Filed January 2000.
21. Pending: System and method for placing an implantable medical device within a body: Iaizzo PA, Laske TG: Filed November 25, 2004.
22. Pending: Ergonomic rake and handling methods: Iaizzo PA, Augustine SA: Filed April 12, 2006.
23. Pending: Method of handling ergonomic rake: Iaizzo PA, Augustine SA: Filed September 21, 2006.
24. Pending: Novel lead fixation means: Iaizzo PA, Laske TG: Filed August 11, 2006.
25. Pending. Percutaneous atrial and ventricular septal defect closure device: Iaizzo PA, Rothestein P: Filed August 2012.
26. Patent Board Approved for Filing: Algorithm and device to determine fixation state for an implantable pacing device: Eggen M, Haddad T, Iaizzo PA, Yang Z: Filed April 8, 2013.

European Patent Office

1. EP1009342A1: An inflatable thermal blanket for convectively and evaporatively cooling a body. Augustine SD, Iaizzo PA: Issued September 25, 1998.
2. Pending: Use of an isolated perfused heart preparation for device design and medical imaging (P-8207.00): Laske TG, Iaizzo PA, Hjelle MA, Morissette J, Wahlstrom DA: Filed October 22, 1999.
3. 01973198.3-2305-US0129289: Improved system and method for determining tissue contact of an implantable medical device within a body. Iaizzo PA, Laske TG: Filed May 7, 2003.
4. EP1009342, DE69827277D: Inflatable thermal blanket for convectively cooling a body. Augustine SD, Iaizzo PA: Filed August 26, 1997.

Provisional Patents/IP Filed

1. Z09140 Implantable composite catheter.  Richardson ES, Whitson BA, Rolfes CD, Iaizzo PA, Benditt DG: Filed January, 2010.
2. OTC Docket No.: 20100107. Novel methods for teaching ultrasound diagnostic techniques. Iaizzo PA, January 2010.

Marketed Invention

Slapshot Ergonomic Hockey Rake, Augustine Biomedical and Design, 2005, sold on QVC.